Acroangiodermatitis (pseudo-Kaposi's sarcoma) in an HIV sero-positive
patient with syphilis and hepatitis C virus coinfection: clinical and
dermatopathological features |
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| Authors: | Fred Bernardes Filho Gustavo Martins José Augusto da Costa Nery Cecília Vianna de Andrade Bernard Kawa Kac |
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| Affiliation: | 1. Instituto de Dermatologia Professor Rubem David Azulay - Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA - SCMRJ) - Rio de Janeiro (RJ), Brazil.;2. Private clinic - Ituiutaba (MG), Brazil.;3. Fundação Oswaldo Cruz (Fiocruz) - Rio de Janeiro (RJ), Brazil.;4. Laboratório Fonte MD - Niterói (RJ), Brazil.;5. Laboratório Anatomical lab - Rio de Janeiro (RJ), Brazil. |
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| Abstract: | Acroangiodermatitis is an angioproliferative disease usually related to chronicvenous insufficiency, and it is considered a clinical and histological simulator ofKaposi''s sarcoma (KS). Immunohistochemistry is the suitable method to differentiatebetween these two entities. It reveals the following immunostaining profile:immunopositivity with anti-CD34 antibody is restricted to the vascular endothelium inacroangiodermatitis, and diffuse in the KS (endothelial cells and perivascularspindle cells); immunopositivity with anti-HHV-8 only in KS cases. We report the caseof an HIV seropositive patient without apparent vascular disease, who presentedviolaceous and brownish erythematous lesions on the feet, and whose histopathologyand immunohistochemistry indicated the diagnosis of acroangiodermatitis. |
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| Keywords: | AIDS Serodiagnosis Herpesvirus 8 human Immunohistochemistry Sarcoma Kaposi Syphilis cutaneous |
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