The immune checkpoints CTLA-4 and PD-L1 in carcinomas of the uterine cervix |
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| Institution: | 1. Wuhan University Health Sciences Center, Wuhan 430071, Hubei, China;2. Department Of Gynecology and Obstetrics, People''s Hospital of Jiangxi Province, Nanchang 330006, Jiangxi, China;3. Graduate School of Nanchang University, Nanchang 330006, Jiangxi, China;1. Department of Pathology, Jawahar Lal Nehru Medical College, Aligarh Muslim University, Aligarh, India;2. Department of Obstetrics and Gynaecology, Jawahar Lal Nehru Medical College, Aligarh Muslim University, Aligarh, India |
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| Abstract: | BackgroundEvasion of immune control is a major feature of malignant tumors. This tumor aspect is poorly studied in cervical lesions.Aim of the studyTo investigate the expression of PD-L1 and CTLA-4 in lesions of the uterine cervix.Material and methodsSixty-three cervical lesions from 52 patients were immunohistochemically studied. The 63 lesions included 27 invasive adenocarcinomas, 19 squamous cell carcinomas (SCCs), 7 adenocarcinomas in situ, and 10 high-grade squamous intraepithelial lesions (CIN3).ResultsCTLA-4 and PD-L1 tumor cell expression was found in 61.5 % and 26.9 % of the invasive cases, respectively. CTLA-4 tumor cell expression and PD-L1 tumor and immune cell expression were more often found in SCCs than in adenocarcinomas. CTLA-4 tumor cell expression was more often found in advanced FIGO tumors. PD-L1 and CTLA-4 immune cell expression was associated with lymph node metastasis. CTLA-4 expression did not affect survival. The prognosis was worse for PD-L1-expressing tumors.ConclusionCTLA-4 and PD-L1 are potential therapeutic targets in cervical cancer. |
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| Keywords: | Immunopathology Adenocarcinoma Dysplasia Cervical Lymphocytes Prognosis Immunotherapy |
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