Immunohistopathological spectrum in cutaneous tuberculosis |
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| Authors: | V. N. SEHGAL,R. GUPTA&dagger ,M. BOSE&Dagger ,K. SAHA§ |
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| Affiliation: | Department of Dermatology and STD, Lady Hardinge Medical College and associated hospitals;Department of Dermatology and Venereology, Maulana Azad Medical College and associated hospitals. New Delhi;Department of Microbiology V. P. Chest Institute. University of Delhi, Delhi, India;Department of Immunology, V. P. Chest Institute. University of Delhi, Delhi, India |
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| Abstract: | Granulomas of lupus vulgaris were characterized by a raised CD4+/CD8+ ratio, while in scrofuloderma this was significantly decreased. Tuberculosis verrucosa cutis showed intermediate changes. These immunological variations suggest that cutaneous tuberculosis forms a spectrum with strong cell-mediated immunity seen in lupus vulgaris, and weaker cell-mediated responses in scrofuloderma; tuberculosis verrucosa cutis is intermediate between the two. |
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