Molecular genetic epidemiology of age-related hearing impairment |
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| Authors: | Uchida Yasue Sugiura Saiko Ando Fujiko Nakashima Tsutomu Shimokata Hiroshi |
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| Affiliation: | aDepartment of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Japan;bDepartment of Health and Medical Sciences, Aichi Shukutoku University, Japan;cDepartment for Development of Preventive Medicine, National Center for Geriatrics and Gerontology, Japan;dDepartment of Otorhinolaryngology, Nagoya University School of Medicine, Japan |
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| Abstract: | Genetic epidemiology focuses on the genetic determinants in the etiology of disease among populations and seeks to elucidate the role of genetic factors and their interaction with environmental factors in disease occurrence. In recent years, genetic epidemiological research has become more focused on complex diseases, and human genome analysis technology has made remarkable advances.Age-related hearing impairment (ARHI) is a complex trait, which results from a multitude of confounding intrinsic and extrinsic factors. Although the number of genetic investigations of ARHI is increasing at a surprising rate, the etiology of ARHI is not firmly established.In this article, we review (1) the methodological strategies used to analyze genetic factors that contribute to human ARHI, (2) several representative investigations, and (3) specific genetic risk factors for human ARHI identified in previous work. |
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| Keywords: | Single nucleotide polymorphism Age-related hearing impairment Linkage analysis Association study |
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