南昌市2004-2010年乙肝流行趋势及聚类分析

目的 分析南昌市2004 - 2010年乙型病毒性肝炎(简称乙肝)流行趋势,探索乙肝发病率年龄和地区差异,为进一步探讨防治策略提供科学依据.方法 描述2004 - 2010年乙肝发病趋势,采用动态样品聚类法对乙肝发病率进行聚类分析.结果 2004 - 2010年共报告乙肝发病36557例,平均发病率为113.07/10万,女性发病率(57.20/10万)低于男性(165.34/10万)(x2=52.60,P＜0.001),总体发病率略呈下降趋势.聚类分析结果显示,按发病率高低可分为3类:高发地区(进贤县)、中发地区(青山湖区等)、低发地区(东湖区等),年均发病率分别为190.63/10万、108.02/10万～125.77/10万、67.19/10万～90.37/10万；乙肝高发年龄为15～59岁.结论 乙 .肝发病率存在明显地区差异,男性青壮年为乙肝发病的重点人群,预防乙肝应在提高新生儿乙肝疫苗接种率的基础上,加强对其他人群尤其是男性青壮年人群的接种工作.

Epidemic trend and clustering analysis of hepatitis B incidence rate in Nanchang City, 2004 - 2010

Objective To analyze the epidemic trend of hepatitis B,2004-2010,explore the age and regional differences in Nanchang City,so as to provide scientific basis for the future control strategy.Methods The epidemiological characteristics of hepatitis B was described and the K-means clustering method was used to analyze the data.Results There were 36 557 patients in all.The average of incidence rate was 113.07/100 000.The incidence of men（165.34/100 000） was higher than that of women（57.20/100 000）.It indicated a decreasing trend for the whole population.It was divided into three levels according to hepatitis B incidence rates： regions with high incidence rates（Jinxian）,regions with medium incidence rates（Qingshanhu,ect.） and regions with low incidence rate（Donghu,ect.）.The annual average morbidity were 190.63/100 000,108.02/100 000～125.77/100 000,67.19/100 000～90.37/100 000 respectively.The age range with high incidence rates was from 15 to 59 years.Conclusions There are regional differences of hepatitis B incidence rates in Nanchang City,young adult men are the risk groups of hepatitis B.The immunization of hepatitis B vaccine should be enhanced for other groups,especially for the high risk population on the basis of improving of immunization coverage rate for newborns.