大连市海岛居民血清高敏C反应蛋白水平与原发性高血压关系研究

目的 探讨海岛居民血清高敏C反应蛋白(high sensitive C-reactive protein,HS-CRP)浓度与高血压的关系.方法 对119例原发性高血压患者和119例年龄、性别相匹配的正常对照者进行问卷调查,了解其一般情况及高血压家族史等相关信息,并测量血压,采集空腹静脉血测定血清HS-CRP、尿酸、血糖、胆固醇、甘油三酯等生化指标.比较病例组和对照组血清HS-CRP水平的差异,并用多因素Logistic回归模型分析高血压的危险因素.结果 高血压组HS-CRP水平高于对照组,并且血压值随着HS-CRP水平的增加而增加.在高血压危险因素的单因素分析中,以第一分位HS-CRP为参比,第四分位血清HS-CRP是高血压的危险因素(OR=2.13,95％ CI:1.03～4.37).在校正其他因素影响后,血清HS-CRP与高血压无统计学关联.结论 海岛居民中原发性高血压患者血清HS-CRP水平较正常对照者增高,但校正混杂因素后关联消失,提示血清HS-CRP可能不是高血压的一个独立危险因素.

Relationship between high sensitive C-reactive protein and essential hypertension in island residents in Dalian City

Objective To explore the relationship between high sensitive C-reactive protein（HS-CRP） and essential hypertension in the island residents.Methods A total of 119 patients with hypertension and 119 sex-and age-matched normotensive people were selected as participants for the case-control study.Blood pressure,HS-CRP,total cholesterol,total triglycerides,high density lipoprotein cholesterol,blood glucose,uric acid,and other biochemical markers were examined,the lifestyle risk factors and family history of hypertension were investigated for all participants.Results The levels of HS-CRP were significantly higher in hypertensive group than that in normotensive group and blood pressures were increased with the HS-CRP levels.The participants were divided into quartiles of HS-CRP,compared to the lowest quartile,the highest level of HS-CRP were associated with hypertension（OR=2.13,95% CI：1.03～4.37）.After adjustment for covariates,serum HS-CRP was not associated with hypertension,serum uric acid,cholesterol,high blood pressure and body mass index entered into the Logistic regression model.Conclusions Increased HSCRP was associated with essential hypertension,however,the association disappeared after adjustment for covariates,suggesting that serum HS-CRP may not be an independent risk factor of hypertension in the island residents.