奥普力农改善心力衰竭疗效的临床观察

目的观察奥普力农改善心力衰竭的疗效与安全性。方法72例心力衰竭患者随机分为治疗组(36例)与对照组(36例),治疗组采用奥普力农注射液治疗,对照组采用米力农注射液治疗。对比两组的NYHA疗效与Boston心衰计分疗效。结果NYHA心功能疗效治疗组总有效率为94.4%,对照组为80.6%;Boston心功能疗效治疗组总有效率为69.4%,对照组为61.1%。治疗组虽然疗效有增加趋势,但无统计学差异(P>0.05);不良反应发生率方面治疗组5.56%,对照组30%,存在统计学差异(P<0.01)。其它超声心动等观察指标两组无统计学差异。结论奥普力农改善心力衰竭疗效与米力农相当,但不良反应发生率明显减少。

Clinical Observation on Olprinone Improving the Treatment Effect of Heart Failure

Objective To observe the treatment effect and safety of Olprinone improving heart failure.Methods 72 cases of patients with heart failure were divided randomly into treatment group(36 cases) and control group(36 cases).Treatment group were treated with Olprinone injection,while control group were treated with Milrinone injection.The NYHA effect and Boston heart failure scoring effect of the two groups were compared.Results As to the NYHA heart function effect,the total efficient rate of treatment group was 94.4%,while that of control group was 80.6%.As to the Boston heart function effect,the total efficient rate of treatment group was 69.4%,while that of control group was 61.1%.The effect of treatment group had upward trend,but there was no significant difference(P >0.05).The incidence of adverse reactions of treatment group was 5.56%,while that of control group was 30%.There was significant difference(P <0.01).There was no significant difference in other observing indexes of two groups.Conclusion Olprinone had the considerable treatment effect as Milrinone in improving heart failure,but the incidence of adverse reactions decreased significantly.