| Expressions of IL-10 on leukemic cells in acute leukemic patients and its significance |
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| 作者姓名： | Yun Yang Wanggang Zhang Yichao Qiao yinxia Chen Xingmei CAO |
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| 作者单位： | [1]DepartmentofHemotology,theSecondHospitalofXi＇anJiaotongUniversity,Xi＇an710004,China [2]DepartmentofHemotology,theSecondHospitalofXi＇anJiaotongUniversity,Xi＇an710004,China |
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| 摘 要： | Objective: To explore the expressions of IL-10 on leukemic cells in acute leukemia patients and its significance.Methods :The expressions of IL-10 on leukemic cells in thirty patients was measured by indirect immunofluorescence technique. Results:Observed yellow-green bright fluorescence on leukemic cells membrane, the positive rote of cells was 10-80%, there were 18 patients expressing IL-10 (18/30, 60% ) positively, among them 11 with ANLL (11/19, 58% ) and 7 with ALL (7/11, 64% ) respectively while that of peripheral mononucleate cells in control group was 13%. Compared with that in the control group, there was a significant increase of positive rote in ANLL and ALL but with no significant difference between ANLL and ALL. Conclusion: IL-10 secreted by leukemic cells, contributed to the immunosuppressive state at the tumor site. This is probably one of the important mechanisms of acute leukemic escape.
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| 关 键 词： | IL-10 急性白血病 肿瘤细胞 基因表达 |
Expressions of IL-10 on leukemic cells in acute leukemic patients and its significance |
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| Yun Yang,Wanggang Zhang,Yichao Qiao,yinxia Chen,Xingmei CAO.Expressions of IL-10 on leukemic cells in acute leukemic patients and its significance[J].Acta Universitatis Medicinalis Nanjing,2005,19(3):135-138. |
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| Authors: | Yun Yang Wanggang Zhang Yichao Qiao yinxia Chen Xingmei CAO |
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| Institution: | Department of Hemotology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China |
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| Abstract: | Objective: To explore the expressions of IL-10 on leukemic cells in acute leukemia patients and its significance. Methods: The expressions of IL-10 on leukemic cells in thirty patients was measured by indirect immunofluorescence technique. Results: Observed yellow-green bright fluorescence on leukemic cells membrane, the positive rate of cells was 10-80%, there were 18 patients expressing IL-10 (18/30, 60%) positively, among them 11 with ANLL (11/19, 58%) and 7 with ALL (7/11, 64%) respectively while that of peripheral mononucleate cells in control group was 13%. Compared with that in the control group, there was a significant increase of positive rate in ANLL and ALL but with no significant difference between ANLL and ALL. Conclusion: IL-10 secreted by leukemic cells, contributed to the immunosuppressive state at the tumor site. This is probably one of the important mechanisms of acute leukemic escape. |
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| Keywords: | acute leukemia leukemic cells IL-10 |
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