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| 胃肠道恶性肿瘤患者血清AFP、CEA和CA19-9的表达特征探讨 | |
| 引用本文： | 黄素英,黄昌明,田俊,陈华.胃肠道恶性肿瘤患者血清AFP、CEA和CA19-9的表达特征探讨[J].癌变．畸变．突变,2012,24(5):376-378,382. |
| 作者姓名： | 黄素英 黄昌明 田俊 陈华 |
| 作者单位： | 1. 福建医科大学公共卫生学院,福建福州350004;厦门出入境检验检疫局和平办,福建厦门361000 2. 福建医科大学附属协和医院肿瘤外科,福建福州,350001 3. 福建医科大学公共卫生学院,福建福州,350004 |
| 基金项目： | 福建省教育厅科技项目(JB06224);福建医科大学教授基金(JS060018) |
| 摘 要： | 目的:探讨血清肿瘤标志物AFP、CEA和CA19-9在胃肠道恶性肿瘤患者中的表达特征。方法:用罗氏全自动电化学发光分析仪测定126例胃肠道恶性肿瘤患者血清AFP、CEA和CA19-9的表达水平,并分析该3项指标与临床病理因素的关系。结果:血清CEA随着肿瘤浸润深度、临床分期增加以及远处转移而表达水平上升,差异有统计学意义(P0.05);血清CA19-9随着临床分期及远处转移表达水平上升,差异有统计学意义(P0.05)。血清AFP表达水平在不同临床病理因素间无统计学差异(P0.05)。结论:胃肠道恶性肿瘤患者血清CEA、CA19-9的表达水平与胃肠道恶性肿瘤患者的病情密切相关。 |
| 关 键 词： | AFP CEA CA- 胃肠道恶性肿瘤 肿瘤标志物 |
Expression characteristics of serum AFP,CEA and CA19-9 in patients with gastrointestinal malignant tumors |
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| HUANG Su-ying , HUANG Chang-ming , TIAN Jun , CHEN Hua.Expression characteristics of serum AFP,CEA and CA19-9 in patients with gastrointestinal malignant tumors[J].Carcinogenesis,Teratogenesis and Mutagenesis,2012,24(5):376-378,382. | |
| Authors: | HUANG Su-ying HUANG Chang-ming TIAN Jun CHEN Hua |
| Institution: | 1,*) (1.Public Health Academy,Fujian Medical University,Fuzhou 350004;2.Peace Office,Xiamen Entry-Exit Inspection and Quarantine Bureau,Xiamen 361000;3.Surgical Oncology,Fujian Medical University Affiliated Union Hospital,Fuzhou 350001, Fujian,China) |
| Abstract: | OBJECTIVE:To explore expression characteristics of serum tumor markers AFP,CEA,CA19- 9 in patients with the gastrointestinal malignant tumors.METHODS:Expression levels of AFP,CEA,CA19-9 in serum of 126 patients with gastrointestinal cancers were analyzed by Roche automatic electrochemical luminescence,and the relationship of these markers with clinicopathological factors were studied.RESULTS:Serum CEA expression increased with the depth of tumor invasion,clinical stage,and distant metastasis,the difference was statistically significant(P<0.05).Serum CA19-9 expression levels increased significantly with clinical stage,and distant metastasis difference(P<0.05).Serum level of AFP expression was not significantly different between the various clinical pathological factors.CONCLUSION:Expression levels of serum CEA,CA19-9 were closely related to the clinical condition of patients with gastrointestinal cancers. |
| Keywords: | AFP CEA CA19-9 gastrointestinal tumors tumor markers |
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