硫酸镁联合硝苯地平治疗新生儿持续性肺动脉高压临床观察

目的观察硫酸镁联合硝苯地平治疗新生儿持续肺动脉高压(PPHN)的临床效果。方法对收治并确诊的31例PPHN患儿在呼吸支持的基础上采用硫酸镁联合硝苯地平治疗,硫酸镁首剂为200mg/kg,30min内微量泵静脉注入,继之维持量20～50mg/(kg.h)持续微量泵静脉注入,维持4个小时后改用硝苯地平1mg/(kg.次)口服,6～8小时应用一次。治疗期间监测血压、经皮血氧饱和度、血气分析、血钙、血镁和肺动脉压。结果硫酸镁联合硝苯地平治疗后,血氧饱和度、血氧分压、pH值与用药前比较明显改善,肺动脉压下降,差异显著。结论硫酸镁联合硝苯地平治疗新生儿持续肺动脉高压疗效确切,适合基层医院使用。

Clinical Observation on Magnesium Sulfate Combined with Nifedipine in the Treatment of Neonatal Persistent Pulmonary Hypertension

OBJECTIVE To observe the magnesium sulfate combined with nifedipine in the treatment of neonates with persistent pulmonary hypertension（PPHN）clinical effect.METHODS In our hospital and diagnosed in 31 children with PPHN,respiratory support based on the use of magnesium sulfate combined with nifedipine treatment,magnesium sulfate first dose 200 mg kg,30 min micro pump intravenous injection,followed by maintenance dose of 20～50 mg（kg·h）by microinfusion pump intravenous injection,maintained for 4 hours after switching to nifedipine 1 mg（kg·time）oral,6～8 hours once,during treatment and monitoring of blood pressure,transcutaneous oxygen saturation,blood-gas analysis,blood calcium,magnesium,pulmonary artery pressure.RESULTS Magnesium sulfate combined with nifedipine therapy after saturation of blood oxygen,partial pressure of oxygen,pH value before and after treatment is significantly improved,pulmonary artery pressure drop,significant difference.CONCLUSION Magnesium sulfate combined with nifedipine in the treatment of neonates with persistent pulmonary hypertension curative effect,is suitable for hospital use.