| 完全弗氏佐剂诱导前列腺炎模型大鼠尿道腺分泌异常的研究 |
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| 引用本文： | 吴爱宁,熊恩庆,宋波,张恒.完全弗氏佐剂诱导前列腺炎模型大鼠尿道腺分泌异常的研究[J].第三军医大学学报,2009,31(22):2266-2268. |
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| 作者姓名： | 吴爱宁 熊恩庆 宋波 张恒 |
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| 作者单位： | 第三军医大学西南医院全军泌尿外科研究所,重庆,400038 |
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| 摘 要： | 目的 观察前列腺炎对大鼠尿道腺分泌的影响.方法 20只Sprague-Dawley大鼠随机分为前列腺炎组和对照组,前列腺炎组侧叶内给予注射完全弗氏佐剂0.1 ml,对照组给予注射生理盐水0.1 ml,2周后取尿道腺组织做AB-PAS黏液染色和分泌型粘蛋白MUCSAC免疫组化染色.结果 ①前列腺炎组前列腺内大量淋巴细胞、单核细胞浸润,对照组阴性,前列腺炎动物模型建立成功.②AB-PAS黏液特殊染色提示:前列腺炎组大鼠尿道腺细胞的黏液面积、直径、光密度均比对照组高,且差异有统计学意义(P<0.05).③分泌型粘蛋白MUCSAC免疫组化染色结果 提示前列腺炎组粘蛋白面积、平均光密度与对照组相比差异有统计学意义(P<0.05).结论 前列腺炎可以导致尿道腺合成和分泌黏液功能增强,这可能是前列腺患者尿道分泌物增多的原因之一.
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| 关 键 词： | 前列腺炎 尿道腺 分泌 |
Secretory alterations of urethral glands in complete Freund's adjuvant-induced prostatitis in rats |
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| WU Ai-ning,XIONG En-qing,SONG Bo,ZHANG Heng.Secretory alterations of urethral glands in complete Freund's adjuvant-induced prostatitis in rats[J].Acta Academiae Medicinae Militaris Tertiae,2009,31(22):2266-2268. |
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| Authors: | WU Ai-ning XIONG En-qing SONG Bo ZHANG Heng |
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| Institution: | WU Ai-ning,XIONG En-qing,SONG Bo,ZHANG Heng (Urinary Surgery Research Institute,Southwest Hospital,Third Military Medical University,Chongqing 400038,China) |
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| Abstract: | Objective To investigate the effects of prostatitis on secretory alterations of urethral glands in rats.Methods Twenty adult Sprague-Dawley rats were randomly divided into prostatitis group and control group.The prostatitis group(n=10) was injected with 0.1 ml Freund's complete adjuvant at each lateral lobe while the control group(n=10) with 0.1 ml 0.9% physiological saline.Two weeks later the rats were killed and the urethral glands were harvested for pathologic examination and immunohistochemical staining... |
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| Keywords: | prostatitis urethral glands secretion |
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