A case of pure red cell aplasia and systemic lupus erythematosus caused by human parvovirus B19 infection |
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Authors: | Haruko Ideguchi Shigeru Ohno Yoshiaki Ishigatsubo |
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Institution: | (1) Chronic Intractable Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa 232-0024, Japan;(2) Department of Internal Medicine and Clinical Immunology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan |
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Abstract: | Human parvovirus B19 (B19) rarely induces pure red cell aplasia (PRCA) in healthy hosts. Meanwhile B19 infection is often
clinically similar to systemic lupus erythematosus (SLE), and several cases have been reported wherein B19 actually stimulated
SLE exacerbation in an immunocompetent subject. An 82-year-old healthy woman was diagnosed to have complicated with B19 infection
and PRCA. Four weeks later, she had high fever, polyarthritis, and oral ulcers, additionally diagnosed with SLE, and subsequently,
15 mg of prednisone was started. This is the first case wherein B19 infection caused both PRCA and SLE in a healthy patient
as far as our investigations are concerned. |
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Keywords: | Pure red cell aplasia Systemic lupus erythematosus Human parvovirus B19 Healthy subject |
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