腔隙性脑梗死患者的认知损害及其危险因素

目的探讨腔隙性脑梗死(LI)的认知损害及其危险因素。方法对41例LI和25例正常被试进行多种认知测验及对照分析，对认知损害的危险因素进行多元logistic回归。结果LI组的视觉保持测验成绩和韦氏智力量表的总智商、知觉组织因子和记忆/注意因子标准分显著低于正常组。Logistic回归选入高血压病史、合并脑白质疏松(LA）及抑郁症状进入方程。结论LI的认知损害表现为视-空能力缺陷、知觉组织和记忆及注意力障碍。认知障碍的危险因素有高血压病史、合并LA和抑郁。

The cognitive impairment and its risk factors in patients with lacunar infarction

Objective To investigate the cognitive impairmentt and its risk factors in patients with lacunar infarction(LI).Method 41 LI subjects and 25 normal controls were compared on a comprehensive neuropsychological test battery.Logistic regression was used to analysis the risk factors.Result The LI group scored lower on the Visual Retention Test than did the control group.Of the WAIS-RC ,the Full Scale IQ, standard score of the Memory and/ or Freedom From Distractibility factor,and standard score of Perceptural Organization Factor in the LI group were lower than that of the control group.Hypertension,leukoaraiosis(LA)and depression were the correlates of cognitive impairment in Logistic regression analyses.Conclusion LI has some degree of cognitive impairment,especially deficits of visuospatial ability, disfunction of perceptural organization,memory,and attention.Hypertension,leukoa-raiosis (LA), and depression independently contribute to the risk.