| GC法测定棕榈哌泊噻嗪中残留溶剂二甲基亚砜 |
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| 引用本文： | 何晓艳,潘震宇,肖菁. GC法测定棕榈哌泊噻嗪中残留溶剂二甲基亚砜[J]. 中国药师, 2011, 14(12): 1725-1726 |
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| 作者姓名： | 何晓艳 潘震宇 肖菁 |
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| 作者单位： | 湖南省药品检验所 长沙410001 |
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| 基金项目： | 国家药品标准提高研究课题 |
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| 摘 要： | 目的:建立气相色谱(GC)法测定棕榈哌泊噻嗪中二甲基亚砜(DMSO)有机溶剂残留量.方法:采用PC-624毛细管柱(60m×0.32 mm,1.80 μm),FID检测器,检测器温度为230℃,进样口温度为210℃,乙醇为溶剂.结果:二甲基亚砜与溶剂峰完全分离,DMSO在1.22～978.4 μg· ml -浓度范围内线性关系良好(r =0.999 8),平均回收率为99.5％.结论:该方法可用于棕榈哌泊噻嗪中二甲基亚砜残留量测定.
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| 关 键 词： | 气相色谱 棕榈哌泊噻嗪 二甲基亚砜 |
Determination of Residual Solvent Dimethyl Sulfoxide in Pipotiazine Palmitate by Gas Chromatography |
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| He Xiaoyan , Pan Zhenyu , Xiao Jing. Determination of Residual Solvent Dimethyl Sulfoxide in Pipotiazine Palmitate by Gas Chromatography[J]. China Pharmacist, 2011, 14(12): 1725-1726 |
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| Authors: | He Xiaoyan Pan Zhenyu Xiao Jing |
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| Affiliation: | (Hunan Institute for Drug Control, Changsha 410001, China) |
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| Abstract: | Objective ： To establish a gas chromatography method for the determination of residual solvent dimethyl sulfoxide in pipofiazine palmitate. Method： A PC-624 capillary column （60 m ×0. 32 mm, 1.80 μm） and hydrogen flame ionization detector （FID） were applied in the study. The detector temperature was 230℃ and the sample-input temperature was 210 ℃ with ethanol as the solvent. Result： The established method could separate dimethyl sulfoxide （DMSO） and the solvent completely, and DMSO had a good linearity within the range of 1.22-978.40 μg·ml-1 （r = 0. 999 8）. The average recovery was 99. 5%. Conclusion： It is practicable to apply the method in the determination of dimethyl sulfoxide in pipotiazine palmitate. |
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| Keywords: | GC Pipotiazine palmitate Dimethyl sulfoxide |
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