奥氮平与利培酮治疗酒精所致精神障碍对照研究

目的：比较奥氮平与利培酮治疗酒精所致精神障碍的疗效和安全性。方法：将60例酒精所致精神障碍患者随机分成两组。每组各30例。分别给予奥氮平和利培酮治疗，疗程8周。采用阳性与阴性症状量表（PANSS），治疗中出现的副反应量表（TESS）评定疗效及不良反应。结果：两组PANSS总分均较治疗前显著下降（P〈0．05），奥氮平组显进率80．0％，利培酮组显进率73．3％，两组疗效相仿（P〉0．05）。奥氮平组嗜睡、体重增加、血脂升高的不良反应明显高于利培酮（P〈0．05）．利培酮组锥体外系反应、失眠、兴奋或激惹均明显高于奥氮平组（P〈0．05）。结论：奥氮平与利培酮对酒精所致精神障碍的疗效相当，安全性较高。，

Comparative study of olanzapine and risperidone in the treatment of mental disorders due to use of alcohol

Objective：To compare the efficacy and safety of olanzapine and risperidone in the treatment of mental disorders due to use of alcohol. Methods： 60 patients were randomly assigned to olanzapine group or risperidone group respectively for 8 weeks. The positive and negative symptom scale（PANSS） and treatment emergent symptoms scale（TESS） were used to evaluate efficacy and side effects. Results： Marked improvement rate of olanzapine group was 80. 0% , and risperidone group was 73. 3% , the efficacy was similar in two groups（ P 〉 0. 05 ） ; side effects of olanzapine were drowsiness, increase of body weight and blood pressure ,which were obviously more frequent than in risperidone （P 〈 0. 05 ） ;the main side effects of risperidone were extrapyramidal side effects and insomnia or excitement, which were more frequent than those in olanzapine group （ P 〈 0. 05 ）. Conclusion ： olanzapine had similar effects to risperidone in the treatment of mental disorders due to use of alcohol They have high safety.