血管外膜原位干/祖细胞研究现状及进展

传统的观点认为血管外膜作为疏松结缔组织,包含了成纤维细胞、炎症细胞,滋养血管、神经末梢等,仅主要起到支撑、营养血管的作用.然而,近年越来越多的证据表明血管外膜中存在原位干/祖细胞.在病理情况下,这些血管壁原位干/祖细胞分化为内皮细胞或平滑肌细胞,从而参与动脉粥样硬化的进展、血管损伤后的修复与重构等.本文将对血管外膜原位干/祖细胞的研究现状及进展作一综述.

Research Status and Progress of Resident Stem/Progenitor Cells in Adventitia

Traditionally, the tunica adventitia has been regarded as loose connective tissue, which was composed of fibroblasts, inflammatory cells, vasa vasorum, nerve endings and so on. It mainly functioned as supportive tissue and supplied nutrition to the vessel wall. Recently, accumulating data suggested that stem/progenitor cells were present in the adventitia. Under pathological conditions, resident stem/progenitor cells in the adventitia could differentiate into endothelial cells or smooth muscle cells, which were involved in atherosclerosis, vascular repair and remolding. This article briefly reviews the research status and advancement of stem/progenitors in adventitia.