骨性关节炎患者退变软骨及滑膜组织中细胞因子的表达

背景：骨性关节炎的炎症反应是Fh软骨细胞、滑膜组织分泌的细胞因子所介导的。关节软骨和滑膜组织内含有多种细胞因子，在关节软骨的损伤修复中起着重要的调节作用。目的：分析软骨细胞、滑膜组织分泌的细胞因子与骨性关节炎发病的关系及影响。方法：由第一作者应用计算机检索万方数据库（WWW．wanfangdata．com．cn），PubMed数据库（www．ncbi．nIm．nih．guv／pubmed）检索时间：2005至2010年。检索词为“骨性关节炎，退变，软骨组织，细胞因子”。计算机初检得到146篇文献，阅读标题和摘要进行初筛，排除因研究目的与此文无关的86篇，内容重复性的研究40篇，保留21篇骨性关节炎患者退变软骨及滑膜组织中各种细胞因子作用及影响的相关文献作进一步分析。结果与结论：细胞因子主要是指活化的免疫细胞和某些基质细胞分泌的一类非特异调节免疫应答和介导炎症反应的小分子蛋白质，包括由淋巴细胞产生的淋巴因子，单核巨噬细胞产生的单核因子及其他细胞因子等。关节滑膜细胞分泌的细胞因子可部分解释骨性关节炎的病理过程，在炎症关节中起着重要的作用。虽然越来越多的学者重视到滑膜细胞、软骨细胞分泌细胞因子的作用，但主要是研究外源性细胞因子对软骨细胞或滑膜细胞的影响，而其内源性细胞因子在骨性关节炎发病中的作用却未广泛开展研究。

Expression of cytokines in the degenerative cartilages and synovial tissues of osteoarthritis patients

BACKGROUND： The inflammation of osteoarthritis is mediated by chondrocytes and the synovial tissue-secreted cytokines. Articular cartilage and synovial tissue contains a variety of cytokines, which play important regulatory role in the repair of articular cartilage injury. OBJECTIVE： To analyze the relationship between chondrocytes, synovial tissue-secreted cytokines and osteoarthritis, as well as the effect of chondrocytes and synovial tissue-secreted cytokines on osteoarthritis. METHODS： A computer-based search was conducted in Wanfang database （www.wanfangdata.com.cn）, PubMed database （www.ncbi.nlm.nih.guv/pubmed） by the first author from 2005 to 2010. The key words were ＂osteoarthritis, degeneration, cartilage tissue, cytokines＂. A total of 146 articles were obtained through computer search, then reading the titles and abstracts for initial screen, 86 articles with the unrelated research purposes were eliminated, 40 articles with the repetitive content were excluded, and finally 21 articles related to the effect of various cytokines in the degenerative cartilage and synovial tissue of the osteoarthritis patients were included for further analysis. RESULTS AND CONCLUSION： The cytokines mainly refers to the activated immune ceils and some stroma~ cell-secreted non-specific regulate immune responses and inflammatory responses-mediated small molecule proteins, including lymphokines produced by the lymphocytes, as well as the single nuclear factor and other cytokines produced by monocytes macrophages. Synovial cell-secreted cytokines may partially explain the pathological process of osteoarthritis and play an important role in joint inflammation. Although, more and more scholars have pay attention to the effect of synovial cells and cartilage cell-secreted cytokines, but mainly studies the effect of exogenous cytokines on chondrocytes or synovial calls, and the effect of endogenous cytokines in the pathogenesis of osteoarthritis has not been extensively studied.