| 蝮蛇毒抗栓酶的促纤溶和抗凝血作用的实验研究 |
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| 引用本文： | 朱广瑾 张杼扬. 蝮蛇毒抗栓酶的促纤溶和抗凝血作用的实验研究[J]. 基础医学与临床, 1991, 11(5): 22-25 |
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| 作者姓名： | 朱广瑾 张杼扬 |
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| 作者单位： | 中国医学科学院基础医学研究所病理生理研究室(朱广瑾，周朝凤，段岩平，金淑敏)，北京协和医院内科心组(张杼扬，金兰)，北京协和医院内科心组(方圻) |
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| 摘 要： | 本工作利用大鼠衄管灌流及异丙肾上腺素(ISP)性AMI模型,以体外纤维蛋白溶解活性、纤溶酶原激活剂(PA)活性,血浆纤溶酶(PL)活性、凝血酶原时间(PT)、白陶土部分凝血活酶时间(KPTT)等变化,观察蛇毒抗栓酶(SVATE)的促纤溶、抗凝血和心肌保护作用。结果表明,SVATE有缴活纤溶怍用,它能逆转ISP性AMI大鼠PL活性的降低,这种作用是由于激活PA导致PL生成增加。同时对内源凝血系统有一定抑制作用。此外保护心肌、降低死亡率。
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| 关 键 词： | 心肌梗塞 蝮蛇毒抗栓酶 纤溶活性 |
Effects of Snake Venom Antithrombus Enzyme ( SVATE ) on Fibrinolysis and Anticoagulation in Rat |
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| Zhu Guangjin Zhang Shuyang Zhou Chaofeng Duan Yanping Jin ShuminJin Lan Fang Qi. Effects of Snake Venom Antithrombus Enzyme ( SVATE ) on Fibrinolysis and Anticoagulation in Rat[J]. Basic Medical Sciences and Clinics, 1991, 11(5): 22-25 |
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| Authors: | Zhu Guangjin Zhang Shuyang Zhou Chaofeng Duan Yanping Jin ShuminJin Lan Fang Qi |
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| Abstract: | Effects of SVATE on fibrinolysis and anticoagulation were observed in rat vascular perfused and isoproterenal AMI models.SVATE perfusion induced a significant increase in plasminogen activator (PA)activity.Administration of SVATE in vivo resulted in the recoverey of the plasmin(PL)activity , increased KPTT and survival in AMI rat.These suggest that SVATE may stimulate fibrinolytic activity and inhibit endogenous coagulative system. |
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| Keywords: | snake venom antithrombus enzyme (SVATE) plasmiaogen activator (PA) plasmin (PL) acute myocardial infarction(AMI) |
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