重症肌无力患者IgG脑室内注射对大鼠EEG及BAEP的影响

目的 观察重症肌无力(myasthenia gravis，MG)患者IgG(AChRAb)经大鼠脑室内注入对其脑电图(electroencephalography，EEG)及脑干听觉诱发电位(brain stem auditory evoked potential，BAEP)的影响，并探讨AChRAb影响大鼠中枢神经系统(CNS)的机制。方法将从确诊的、AChRAb阳性的MG患者血清中提纯的IgG(AChRAb)，注射到实验组大鼠侧脑室，对照组大鼠则注射健康人IgG，观察大鼠行为学、BAEP、EEG改变。结果实验组大鼠术后出现类似于实验性自身免疫性MG的行为学改变，部分大鼠出现癫痫发作BAEP峰间潜伏期(IPLs)延长EEG异常，即δ、θ增多与痫性波发放增加。结论 MGAChRAb可致大鼠CNS损害，AChRAb与大鼠CNS神经元型乙酰胆碱受体结合，可能是其病理生理机制。

The Effect of AChRAb Injected to Lateral Ventricle on Rats BAEP and EEG

Objective To observe the effects of nicotinic acetylcholine receptor antibody (AChRAb) on rats brainstem auditory evoked potential (BAEP) and electroencephalography(EEG) as well as mechanism. Methods IgG (containing AChRAb) purified from myasthenia gravis patients sera was injected to the models lateral ventricle, and the same injections were performed on the control with the IgG derived from healthy volunteers. The rats BAEP and EEG were examined one day before and two weeks after the injections.Results While after the injections, the model rats showed abnormal behavior, as well as abnormal BAEP and EEG were observed. Conclusions The results suggested that AChRAb may cause rats CNS dysfunction.