神经细胞黏附分子49例涎腺腺样囊性癌表达及临床意义

目的]探讨神经细胞黏附分子（NCAM）在涎腺腺样囊性癌（SACC）中的表达及临床意义。方法]应用免疫组织化学方法检测49例涎腺腺样囊性癌中NCAM的表达情况。结果]NCAM阳性表达率为57.14%（28/49）。NCAM在涎腺腺样囊性癌的表达与患者性别、肿瘤部位、原发灶分期无相关性。NCAM阳性表达率在管状型与实性型有显著性差异（χ^2=4.07,P=0.04）。有无神经侵犯NCAM阳性表达存在显著性差异（χ^2=10.02,P〈0.05）。结论]神经细胞黏附分子与涎腺腺样囊性癌的神经侵袭性显著相关,NCAM在SACC中起到了重要作用。

Expression of Neural Cell Adhesion Molecule in 49 Cases with Salivary Adenoid Cystic Carcinoma and its Significance

Purpose]To investigate expression of neural cell adhesion molecule （NCAM） in salivary adenoid cystic carcinoma（SACC） and its clinical significance. Methods] The expression of NCAM in 49 cases with SACC was detected by immunohistochemical technique. Results] The positive rate of NCAM was 57.14%（28/49）. NCAM expression was not related to gender, tumor site and staging. NCAM expressions in SACC tubular subtype and in solid subtype were significantly different （χ2=4.07,P=0.04）. NCAM expression with neural invasion was significantly higher than that without neural invasion （P〈0.05）. Conclusion] The NCAM closely correlates to neural invasion in SACC. NCAM plays an important role in neural invasion of SACC.