| 局灶性脑缺血再灌注大鼠IL—1Ra mRNA的表达 |
| |
| 引用本文： | 许贞峰,吴根诚,曹小定. 局灶性脑缺血再灌注大鼠IL—1Ra mRNA的表达[J]. 青岛大学医学院学报, 2001, 37(4): 271-273 |
| |
| 作者姓名： | 许贞峰 吴根诚 曹小定 |
| |
| 作者单位： | 1. 青岛大学医学院脑血管病研究所
2. 复旦大学 |
| |
| 基金项目： | 国家自然基金重点资助项目(39730510) |
| |
| 摘 要： | 目的 观察脑缺血再灌注后白细胞介素 1受体拮抗剂 (IL 1Ra)mRNA的表达。②方法 采用线栓法制备SD大鼠局灶性大脑中动脉阻塞 (MCAO)动物模型 ,应用RT PCR方法观察脑缺血再灌注对大鼠IL 1RamRNA表达的影响。③结果 MCAO模型大鼠缺血侧大脑皮质再灌注后 12 ,2 4h的IL 1RamRNA表达与正常对照组比较明显增加 (F =39.84,q=9.0 3,15 .91,P <0 .0 0 1) ;缺血侧纹状体缺血再灌注后 12h的IL 1RamRNA表达与正常对照组比较明显增加 (F =7.37,q=6 .5 4,P <0 .0 0 1)。④结论 脑缺血后内源性IL 1RamRNA表达增加 ,可能是机体对缺血性损伤的自我保护机制。
|
| 关 键 词： | 脑缺血 再灌注损伤 白细胞介素－1受体 拮抗剂 抑制剂 mRNA IL－1Ra |
| 文章编号： | 1001-4047(2001)04-0271-03 |
| 修稿时间： | 2001-04-19 |
THE EXPRESSION OF IL-1Ra mRNA AFTER FOCAL CEREBRAL ARTERY OCCLUSION IN RATS |
| |
| XU Zhenfeng,WU Gencheng,CAO Xiaoding Cerebrovascular Disease Institute of Qingdao University Medical College,Qingdao . THE EXPRESSION OF IL-1Ra mRNA AFTER FOCAL CEREBRAL ARTERY OCCLUSION IN RATS[J]. Acta Academiae Medicinae Qingdao Universitatis, 2001, 37(4): 271-273 |
| |
| Authors: | XU Zhenfeng WU Gencheng CAO Xiaoding Cerebrovascular Disease Institute of Qingdao University Medical College Qingdao |
| |
| Affiliation: | XU Zhenfeng,WU Gencheng,CAO Xiaoding Cerebrovascular Disease Institute of Qingdao University Medical College,Qingdao 266003 , |
| |
| Abstract: | Objective To investigate the expression of interleukin 1 receptor antagonist (IL 1Ra) mRNA after cerebral ischemia reperfusion in rats. Methods RT PCR was used to explore IL 1Ra mRNA expression in middle cerebral artery occlusion (MCAO) rat model. Results IL 1Ra mRNA expression was rapidly induced after 12 and 24 hours of MCAO reperfusion as compared with the normal control group( F=39.84, q=9.03, 15.91,P <0.001). The expression of IL 1Ra mRNA after 12 hours of reperfusion in ischemic cortex increased markedly compared with the normal control( F=7.34, q=6.54, P <0.001). Conclusion Our results indicated that IL 1Ra mRNA may play an important role in the protection of ischemic brain damage. |
| |
| Keywords: | cerebral ischemia reperfusuin interleukin 1 receptor antagonists and inhibitors |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
