艾滋病合并新型隐球菌脑膜炎临床分析

目的通过对25例艾滋病合并新型隐球菌脑膜炎的临床分析,提高对艾滋病合并新型隐球菌脑膜炎的认识。方法对本院2000年8月—2006年2月收治的25例艾滋病合并新型隐球菌脑膜炎病例进行回顾性分析。结果25例新型隐球菌脑膜炎患者均为艾滋病晚期患者,T细胞亚群检测11例:CD4<50/mm39例,CD450~100/mm32例;平均26.18/mm3。在确诊时已合并多种机会感染。结论艾滋病患者合并新型隐球菌脑膜炎病情重,预后差,实验室病原学检查结果是诊断新型隐球菌脑膜炎的主要依据。

Clinical analysis of AIDS patients coinfected with Cryptococcus neoformans meningitis

Objective The clinical data of 25 cases of acquired immune deficiency syndrome (AIDS) coinfected with Cryptococcus neoformans meningitis were reviewed and analyzed to increase the understanding of AIDS and C. neoformans meningitis coinfection.Methods Twenty-five cases of AIDS coinfected with C. neoformans meningitis admitted from August 2000 to February 2006 were retrospectively reviewed.Results All the 25 cases with C. neoformans meningitis were AIDS patients at advanced stage. T-lymphocyte subpopulation was tested in 11 cases: CD4<50/mm3 in 9 cases; CD4 50-100/mm3 in 2 cases. The mean cell count was 26.18/mm3. Opportunistic infection was established when AIDS was confirmed.Conclusions The clinical condition is serious with poor outcome in AIDS patients coinfected with C. neoformans meningitis. Laboratory test result is the major evidence for diagnosis of C. neoformans meningitis.