NHL in adolescents and young adults: A unique population |
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| Authors: | Jessica Hochberg Allyson Flower Laurence Brugieres Mitchell S. Cairo |
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| Affiliation: | 1. Department of Pediatrics, New York Medical College, Valhalla, New York;2. Department of Microbiology & Immunology, New York Medical College, Valhalla, New York;3. Department of Pediatrics, Institut Gustave Roussy, Villejuif, France;4. Department of Medicine, New York Medical College, Valhalla, New York;5. Department of Pathology, New York Medical College, Valhalla, New York;6. Department of Cell Biology & Anatomy, New York Medical College, Valhalla, New York |
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| Abstract: | Non‐Hodgkin lymphoma (NHL) is a heterogeneous group of lymphoid malignancies with high incidence in adolescents and young adults (AYAs). The most common diseases include diffuse large B‐cell lymphoma, anaplastic large cell lymphoma, Burkitt lymphoma, lymphoblastic lymphoma, and primary mediastinal large B‐cell lymphoma. In comparison to younger children and adults, AYAs (15–39 years) with NHL present a specific set of challenges including variations in tumor biology, inconsistent treatment, pharmacodynamics, and psychosocial barriers. While survival of AYAs with NHL has improved, cure rates remain suboptimal. Incorporation of novel agents into pediatric‐inspired treatment regimens specifically designed for NHL in AYAs has led to improved outcomes. Consideration of AYAs as a distinct population in the diagnosis and treatment of NHL is encouraged. |
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| Keywords: | adolescents B‐cell NHL hematology/oncology lymphoblastic lymphoma non‐Hodgkin lymphoma young adults |
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