Distribution of nickel in lungs from former nickel workers |
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Authors: | K B Svenes I Andersen |
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Institution: | (1) Department of Pathology, Central Hospital of Vest Agder, N-4600 Kristiansand, Norway, NO;(2) Falconbridge Nikkelverk A/S, P.O. Box 457, N-4601 Kristiansand, Norway E-mail: iandersen@falconbridge.no Fax: +47 3810 1011, NO |
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Abstract: | Objective: The purpose of this work was to study the distribution of nickel within lung tissue obtained from nickel-exposed people and
to evaluate the␣use of only one single sample for determination of the nickel burden of the lung. Methods and materials: The material used was lung tissue obtained from 15 former nickel refinery workers who had been exposed to a variety of nickel
compounds such as Ni3S2, NiO, Ni0, NiSO4, and NiCl2. Ten samples taken from different locations of the lung as well as from the right and left bronchus and from the right lower
lobe (total 13 samples per individual) were analyzed for nickel by electrothermal atomic absorption spectrometry. Samples
obtained from ten people not connected to the refinery served as a reference group. Results: The arithmetic mean value ± SD for nickel concentration was 50 ± 150 μg g−1 dry wt. Biopsies collected on the center of the lower right lobe had an average nickel concentration of 82 ± 252 μg g−1. The average nickel concentration detected in the right and left bronchus was 5.9 ± 11.6 and 3.8 ± 6.0 μg g−1, respectively. Lung tissue obtained from ten people not connected to the refinery had an average nickel concentration of
0.74 ± 0.44 μg g−1. Conclusions: The significant findings based on log-normal distribution of the nickel concentration were as follows: (1) samples obtained
from the right lung showed no significant difference from samples taken from the left lung–a comparison of the nickel concentration
detected in all the lung lobes showed that no single lobe differed from another; (2) the concentration of nickel found in
the main bronchus of the refinery workers, although elevated, was significantly lower than the concentration detected in the
remaining tissue; and (3) one single biopsy did not reflect the nickel burden of the lung.
Received: 20 November 1997 / Accepted: 21 April 1998 |
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Keywords: | Lung Autopsy Nickel distribution Lung cancer |
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