EGFR在乳腺癌组织中的表达与临床病理特征相关性

目的:探讨肿瘤组织中EGFR的分布特点及其与乳腺癌的组织学分级、肿瘤大小、腋窝淋巴结转移、雌孕激素受体的关系,为乳腺癌的临床诊断、指导临床治疗及预后提供重要依据.方法:病例取材及苏木精伊红(HE)染色;利用免疫组化法检测42例浸润性乳腺癌组织EGFR的表达情况.结果:①42例乳腺癌组织中EGFR(+)表达百分率为4.8％,EGFR(-)或(±)表达百分率为95.2％.②EGFR的表达与患者是否绝经、肿瘤的大小、淋巴结转移与否和组织学分级Ⅱ与Ⅲ之间比较差异无统计学意义(P＞0.05)；但在组织学分级Ⅰ与Ⅱ,淋巴结转移＜4枚与淋巴结≥4的患者间比较,差异具有统计学意义(P＜0.05).③EGFR的表达与ER、PR结果之间比较,差异无统计学意义(P＞0.05),在ER(-)、PR(-)的患者中,EGFR的表达阳性率低；患者的HER2(-)与HER2(+)、HER2(+)与HER2(+++)、HER2(++)与HER2(+++)之间比较,差异无统计学意义(P＞0.05),但HER2(-)与 HER2(++)、HER2(+++),HER2(+)与HER2(++)之间比较,差异具有统计学意义(P＜0.05).结论:①EGFR在乳腺癌中的表达与患者月经状态、肿瘤大小、组织学分级和淋巴结累及情况均无明确关联性.②EGFR的表达与ER、PR表达状况无关联性.EGFR在HER2强阳性乳腺癌患者中的表达明显高于HER2阴性患者,可能与乳腺癌侵袭、转移和预后存在关联性.③EGFR的表达与乳腺癌腋窝淋巴结累及情况无关,但随着淋巴结转移数量的增加,其阳性表达率明显增高.

The Correlation Investigation of EGFR Expression in Breast Cancer and Clinical Pathological Features

Objective:To investigate their distribution characteristic in the breast cancer and its relationship with the breast cancer histological grade,tumor size,axillary lymph node metastasis,estrogen and progesterone receptors.Provide an important basis on diagnosis,clinical treatment and prognosis of the breast cancer.Methods:Material taking and hematoxylin and eosin(HE) staining,Detect the expression of EGFR in 42 cases of breast cancer in the method of immunohistochemistry.Analysis the expression of the CK5/6 and EGFR in breast cancer tissue.Results:①The positive rate of EGFR is 4.8% in 42 cases of breast cancer tissues,the negative rate is 95.2%.②The relationship between the expression of EGFR menopause,tumor size,lymph node metastasis,pathological gradeⅡand Ⅲ is not statistically significant(P>0.05),but the comparation of pathological gradeⅠandⅡ,axillary lymph node metastasis is less than 4 and greater than or equal to 4 are significant differences(P<0.05).③There is no difference(P>0.05) in the comparison between EGFR expression and ER,PR results,In the patients of ER(-),PR(-),the EGFR expression was lower,There is no significantly difference(P>0.05) in comparison between the patients with HER2(-) and HER2(+),HER2(+) and HER2(+++),HER2(++) and HER2(+++).however,there is statistical difference(P<0.05) in the comparison among HER2(-) and HER2(++),HER2(+++),HER2(+) and HER2(++).Conclusion:①The expressions of EGFR in breast cancer tissue are not related to menopause,tumor size,pathological grade,lymph node status.②The expressions of EGFR are not related to ER and PR status.The expressions of EGFR in HER2 high positive breasr cancer are more than in the HER2 negative breast cancer.That suggest the expression of EGFR are correlate to the invasion,metastasis and prognosis of breast cancer.③The expressions of EGFR in breast cancer are not related to lymph node status,but there are high positive rates in more axillary lymph node metastasis.