In vivo incorporation of [14C]leucine into brain protein of mice treated with methylmercury and thiol complexes of methylmercury |
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| Authors: | P H Fair J E Balthrop J L Wade S Braddon-Galloway |
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| Affiliation: | 1. Guangdong Key Laboratory for New Technology Research of Vegetables/ Vegetable Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;2. Institute of Botany, University of the Punjab, Lahore, Pakistan;3. RO-II Office, University of the Punjab, Lahore;4. Department of Plant Pathology, University of the Punjab, Lahore, Pakistan;5. Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences (CAS), Beijing, China;6. University of Chinese Academy of Sciences (UCAS), Beijing, China |
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| Abstract: | The effect of methylmercury and thiol complexes of methylmercury on inhibition of protein synthesis was evaluated. Mice were injected (i.p.) with the following treatments: methylmercuric chloride, methylmercury-glutathione, methylmercury-cysteinylglycine and control (vehicle) for 10 days. Ten animals from each group were injected with [14C]leucine 90 min prior to death. The brains were removed and the extracted protein was subjected to liquid scintillation analysis. Mice receiving the methylmercury and methylmercury-glutathione treatments exhibited significantly greater weight loss than the control while the methylmercury-cysteinylglycine treatment was not significantly different than the control. Incorporation of [14C]leucine into brain protein was significantly depressed in the methylmercury (81% of control) and the methylmercury-glutathione (79% of control) treatments. Protein synthesis in mice receiving the methylmercury-cysteinylglycine complex although not significantly different than the methylmercury treatments was only 92% of the control mice. |
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