| 阿克他利对佐剂性关节炎大鼠腹腔巨噬细胞分泌IL-1和T淋巴细胞亚群的影响 |
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| 引用本文： | 李卫东,任连生,林志彬.阿克他利对佐剂性关节炎大鼠腹腔巨噬细胞分泌IL-1和T淋巴细胞亚群的影响[J].中国药理学与毒理学杂志,1999,13(3):237-238. |
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| 作者姓名： | 李卫东 任连生 林志彬 |
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| 作者单位： | [1]北京医科大学基础医学院药理系 [2]山西省肿瘤研究所 |
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| 摘 要： | Effects of actarit on production of interleukin-1（IL-1）by peritoneal macrophages from adjuvant arthritis(AA) rats ex vivo and the ratio of subpopulation of T lymphocytes in AA rats ex vivo and the production of hydrogen peroxide （H2O2）by peritoneal macrophages of mice in vitro were studied. The results showed that IL-1 synthesis from the adherent peritoneal macrophages induced with lipopolysaccharide (8 mg·L-1) in AA rats in vivo were inhibited by actarit; the ratio of L3T4+/Lyt-2+ was lowered after administrating actarit; and H2O2 release of the peritoneal macrophages of mice was reduced in dose-dependent manner. The data suggest that the therapeutic effects of actarit on AA rats be related to inhibition of production of IL-1 and reduction of H2O2 release and lowered rat io of L3T4+/Lyt-2+ T-lymophocyte.
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| 关 键 词： | 阿克他利 关节炎佐剂性 白介素-1 T淋巴细胞亚群 过氧化氢 |
| 收稿时间： | 1998-12-16 |
Influence of actarit on IL-1 secretion by peritoneal macrophages and on T subpopulation from adjuvant arthritis rats |
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| LI Wei-Dong, REN Lian-Sheng, LIN Zhi-Bin.Influence of actarit on IL-1 secretion by peritoneal macrophages and on T subpopulation from adjuvant arthritis rats[J].Chinese Journal of Pharmacology and Toxicology,1999,13(3):237-238. |
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| Authors: | LI Wei-Dong REN Lian-Sheng LIN Zhi-Bin |
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| Institution: | （Department of Pharmacology, Basic Medical College, Beijing Medical University, Beijing 100083） |
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| Abstract: | Effects of actarit on production of interleukin-1（IL-1）by peritoneal macrophages from adjuvant arthritis(AA) rats ex vivo and the ratio of subpopulation of T lymphocytes in AA rats ex vivo and the production of hydrogen peroxide （H2O2）by peritoneal macrophages of mice in vitro were studied. The results showed that IL-1 synthesis from the adherent peritoneal macrophages induced with lipopolysaccharide (8 mg·L-1) in AA rats in vivo were inhibited by actarit; the ratio of L3T4+/Lyt-2+ was lowered after administrating actarit; and H2O2 release of the peritoneal macrophages of mice was reduced in dose-dependent manner. The data suggest that the therapeutic effects of actarit on AA rats be related to inhibition of production of IL-1 and reduction of H2O2 release and lowered rat io of L3T4+/Lyt-2+ T- lymophocyte. |
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| Keywords: | actarit arthritis adjuvant interleukin 1 T-lymophocytes hydrogen peroxide |
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