Gal-3与急性心肌梗死后心功能的相关性及瑞舒伐他汀的干预作用

目的：探讨Gal-3与急性心肌梗死患者心功能的相关性,及瑞舒伐他汀的治疗作用。方法：将60例急性心肌梗死患者随机分为A组、B组,每组各30例,所有患者接受急诊PCI治疗,同时应用阿司匹林、氯吡格雷、β受体阻滞剂、钙离子拮抗剂或血管紧张素转换酶抑制剂/血管紧张素抑制剂、依诺肝素等药物。A组口服瑞舒伐他汀10 mg,qn,B组口服瑞舒伐他汀20 mg,qn。患者入院PCI术前,治疗后1周、4周测定Gal-3、NT-pro BNP浓度。入院治疗后24 h、1周、4周测定左室射血分数（LVEF）。结果：（1）治疗后1周两组患者Gal-3水平较PCI术前明显升高（P〈0.05）,NT-pro BNP水平较PCI术前明显降低（P〈0.05）,LVEF较入院24 h升高（P〈0.05）,两组比较差异均无统计学意义。（2）治疗后4周两组患者Gal-3、NT-pro BNP水平均较治疗后1周明显降低（P〈0.05）,LVEF较治疗后1周明显升高（P〈0.05）,B组变化更明显（P〈0.05）。相关性分析表明,Gal-3与NT-pro BNP呈正相关（r=0.72,P〈0.05）,与LVEF呈负相关（r=-0.761,P〈0.05）。结论：AMI患者Gal-3水平与心功能变化呈负相关,可以反映AMI患者的心功能情况;长期大剂量口服瑞舒伐他汀可改善心肌梗死后心肌纤维化,改善心功能。

Effects of Rosuvastatin on Cardic Function and the Relationship between Galectin-3 and Cardic function in Patients with Acute Myocardial Infarction

Objective：To observe the relationship between Galectin-3 and cardic function and the effect of Rosuvastatin on Galectin-3 and cardic function after acute myocardial infarction（AMI）.Method：60 patients with AMI in our hospital were enrolled. They were randomly divided into group A and group B, with 30 cases in each group. All patients were received percutaneous coronary intervention（PCI）.Patients in group A were orally administrated with 10 mg/qn of rosuvastatin, and group B received 20 mg/qn of Rosuvastatin. The levels of Gal-3,NT-pro BNP were measured before PCI and after one week,four weeks;LVEF were measured at 24 h, after PCI one week, four weeks.Result：（1）At one week after PCI, the levels of Gal-3 were increased significantly（P〈0.05）, the levels of NT-pro BNP were decreased significantly（P〈0.05）,LVEF were decreased significantly（P〈0.05）.There were no differences between two groups（P〉0.05）.（2）At four weeks after PCI, compared with one week, the levels of Gal-3 and NTpro BNP were decreased significantly（P〈0.05）,LVEF were decreased significantly（P〈0.05）.Compared with Group A, the changes of Group B were obviously（P〈0.05）. The levels of Gal-3 and NT-pro BNP in patients with AMI was positively correlated（r=0.72,P〈0.05）.The levels of Gal-3 and LVEF in patients with AMI was negative correlated（r=-0.761,P〈0.05）.Conclusion：The levels of Gal-3 and cardic function of AMI is negatively correlated.Early use of higer doses of Rosuvastation can significantly improve cardic of the patients in AMI.