精神分裂症高危人群脑白质弥散张量成像研究 |
| |
引用本文: | 王秀霞,;田峰,;徐勇,;赵婷,;郭晓杰.精神分裂症高危人群脑白质弥散张量成像研究[J].现代保健,2014(13):21-23. |
| |
作者姓名: | 王秀霞 ;田峰 ;徐勇 ;赵婷 ;郭晓杰 |
| |
作者单位: | [1]山西医科大学第二临床医学院,山西太原030001; [2]山西医科大学第二医院;,山西太原030001; [3]山西医科大学第一医院,山西太原030001; |
| |
基金项目: | 国家自然科学基金(81278412) |
| |
摘 要: | 目的:应用磁共振弥散张量成像(DTI)技术,观察精神分裂症高危人群(UHR)脑白质的改变。方法:对15例UHR和17例正常对照进行脑部DTI扫描后,采用基于纤维的空间统计方法(TBSS),比较全脑的各向异性分数值(FA值)。结果:UHR组平均FA值低于对照组,差异有统计学意义(P〈0.05);UHR组与对照组有差异的脑白质位于左侧额叶和左侧内囊前肢。结论:精神分裂症高危人群存在脑白质微结构的改变。
|
关 键 词: | 弥散张量成像 各向异性分数 脑白质 精神分裂症高危人群 |
Diffusion Tensor Imaging Study in White Matter of Ultra-high-risk for Psychosis |
| |
Institution: | WANG Xiu-xia, TIAN Feng, XU Yong, et al.( First-author's address: The Second Clinical Medical School of Shanxi Medical University, Taiyuan 030001, China) |
| |
Abstract: | Objective: To use diffusion tensor imaging (diffusion tensor imaging, DTI) technology to investigate the abnormal changes in white matter of ultra-high-risk for psychosis (UHR). Method: 15 cases of UHR and 17 cases of normal controls underwent a DTI scan,tract-based spatial statistics(TBSS) was performed to measure the fractional anisotropy (FA) of the whole brain.Result: FA mean values of the UHR group was lower than that in the control group, the difference was statistically significant(P〈0.05); there are differences in the two groups of white matter in the left frontal lobe and the left anterior limb of internal capsule.Conclusion:The microstructural of whole-brain white matter was altered in ultra-high-risk for psychosis. |
| |
Keywords: | Diffusion tensor imaging Fractional anisotropy White matter Ultra-high-risk for psychosis |
本文献已被 维普 等数据库收录! |
|