山莨菪碱对急诊心脏骤停患者心肺脑复苏后生活质量的干预影响

目的：探讨山莨菪碱对急诊心脏骤停患者心肺脑复苏后生活质量的干预影响。方法：选取2010年9月-2012年9月本院急诊科经心肺脑复苏抢救的116例心脏骤停患者,按照随机数字表法将其分为观察组59例和对照组57例,对照组给予心肺脑复苏术,观察组在对照组基础上加用山莨菪碱,比较两组患者自主循环恢复率（ROSC）及复苏后24 h存活率、神经功能缺损评分（NFI）与生活质量综合评分的差异。结果：经山莨菪碱药物干预治疗后,复苏后24 h存活率明显提高至32.20%,明显高于对照组的15.79%（P〈0.05）,而ROSC率稍提高但与对照组比较差异无统计学意义（P〉0.05）。随访3个月后,观察组的神经功能缺损评分、平均生活质量综合评分均明显优于对照组（P〈0.05）;在生活质量综合评分方面,身体健康、心理社会功能累积得分均明显高于对照组（P〈0.05）,而物质生活累积得分与对照组比较差异无统计学意义（P〉0.05）。结论：山莨菪碱干预治疗可改善急诊心脏骤停患者心肺脑复苏后的存活状况、神经功能情况及身体健康、心理社会功能相关的生活质量,值得临床推广。

Intervention Effect of Quality of Life in Emergency with Cardiac Arrest Patients Treated with Anisodamine after Cardiopuimonary Cerebral Resuscitation

Objective： To study intervention effect of quality of life in emergency cardiac arrest patients treated with anisodamine after cardiopulmonary cerebral resuscitation.Method： 116 cardiac arrest patients in emergency department from September 2010 to September 2012 were selected, and they were randomly divided into the observation group for 59 cases and the control group for 57 cases, the control group was given cardiopulmonary cerebral resuscitation, the observation group was treated with anisodamine on the basis of control group, return of spontaneous circulation （ ROSC ） and 24 h after resuscitation the survival rate, neurological function deficit score （ NFI ） and comprehensive score of quality of life between the two groups were compared.Result： After anisodamine treatment, 24 h after resuscitation survival rate was increased to 32.20%, it was significantly higher than that of control group （ 15.79% ） （ P〈0.05 ）, while ROSC rate was slightly increased compared with the control group, but comparison with no significant difference （ P〉0.05 ）, after 3 months of follow-up, the neurological deficit scores and average quality of life scores of the observation group were significantly better than the control group （ P〈0.05 ） .In the aspect of comprehensive score of quality life, physical health, psychological and social function of cumulative scores of the observation group were significantly higher than those of control group （ P〈0.05 ）, but material life of the cumulative score compared with the control group had no significant difference （ P〉0.05 ） .Conclusion： Anisodamine intervention treatment can improve the emergency cardiac arrest patients after cardiopulmonary cerebral resuscitation survival condition, nerve function and physical health, psychological and social function related quality of life.It is worthy of clinical oromotion