纳洛酮治疗自由基下急性酒精中毒的临床效果观察

目的：研究探讨纳洛酮治疗自由基下急性酒精中毒的临床效果。方法：选取2012年12月-2013年12月本院收治的202例符合急性酒精中毒诊断标准的急性酒精中毒患者,按照随机数字表法将其分为治疗组和对照组各101例,对照组采用常规治疗,治疗组在常规治疗的基础上加用纳洛酮进行治疗,纳洛酮剂量为：中度酒精中毒为0.4～0.8 mg,重度酒精中毒为0.8 mg或0.4～0.8 mg重复应用。观察比较两组患者的治疗效果、意识恢复时间、住院时间和各临床症状发生情况。结果：治疗组总有效率为89.11%,明显高于对照组的61.38%,且意识恢复时间和住院时间分别为（1.57±0.35）h、（53.81±7.69）h,均明显短于对照组,出现浑身发冷、恶心呕吐、呼吸困难及昏迷的发生率分别为20.79%、15.84%、11.88%及7.92%,均明显低于对照组的57.43%、32.67%、26.73%及16.83%,差异均有统计学意义（P〈0.05）。结论：纳洛酮治疗中重度急性自由基下酒精中毒的疗效较好,意识恢复时间和住院时间均明显减少,值得临床推广应用。

Clinical Efficacy of Naloxone in the Treatment of the Free Radical of Acute Alcoholism

Objective：To study the clinical efficacy of naloxone in the treatment of the free radical of acute alcoholism.Method：220 patients with moderate or severe alcoholism in our hospital from December 2012 to December 2013 were selected,they were randomly divided into the treatment group and the control group,101 cases in each group. The control group was treated with conventional therapy,and the treatment group was treated with naloxone on the basis of the control group,with dosage of 0.4-0.8 mg for moderate patients,0.8 mg or 0.4-0.8 mg for severe patients.The clinical efficacy,consciousness recovery time,length of stay and the occurrence of clinical symptoms between the two groups were observed and compared.Result：The total effective rate of the treatment group （89.11%） was significantly higher than the control group （61.38%）,the consciousness recovery time and length of stay of the treatment group were （1.57±0.35）h,（53.81±7.69）h,they were significantly shorter than the control group,and the incidence of chills, nausea and vomiting,dyspnea and coma of the treatment group（20.79%,15.84%,11.88%,7.92%） were significantly lower than the control group（57.43%,32.67%,26.73%,16.83%）,the differences were statistically significant（P〈0.05）. Conclusion：The efficacy of naloxone in the treatment of the free radical of acute alcoholism is better,with less time of consciousness recovery and length of stay,is worthy of clinical application.