| 甲地孕酮在家兔和大鼠的药物动力学 |
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| 引用本文： | 陈学宁,褚云鸿. 甲地孕酮在家兔和大鼠的药物动力学[J]. 中国医药工业杂志, 1989, 0(12) |
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| 作者姓名： | 陈学宁 褚云鸿 |
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| 作者单位： | 上海医科大学基础医学部药理学教研室，上海医科大学基础医学部药理学教研室 上海 200032，上海 200032 |
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| 摘 要： | 用放射免疫法(RIA)测定甲地孕酮(MA)血清浓度并计算了在家兔和大鼠静注或口服的药物动力学参数。MA口服的生物利用度,家兔为64％,大鼠为56％。MA肝微粒体酶代谢实验提示有极性较MA为大的代谢产物形成,~3H-MA十二指肠给药后30min内门静脉血中放射性远高于外周血,也有极性代谢产物形成。
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| 关 键 词： | 甲地孕酮 药物动力学 放射免疫法 家兔 大鼠 静注 口服 |
PHARMACOKINETICS OF MEGESTROL ACETATE IN RABBITS AND RATS |
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| CHEN Xue-Ning,CHU Yun-Hong. PHARMACOKINETICS OF MEGESTROL ACETATE IN RABBITS AND RATS[J]. , 1989, 0(12) |
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| Authors: | CHEN Xue-Ning CHU Yun-Hong |
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| Abstract: | The pharmacokinetics of megestrsl acetate(MA) was studied byRIA after iv or po administration in rabbits and rats. The bioavailability of MAwas 64% in rabbits, and 56% in rats. The study on metabolism in the livermicrosomal enzyme suggested that the formation of two polar metabolites. Theconcentration of radioactivity in the plasma of portal blood within 30 min afterintraduodenal administration of ~3H-MA exceeded that in peripheral venous blood,and a polar metabolite of MA was also present in portal blood. |
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| Keywords: | megestrol acetate pharmacokinetics radioimmunoassay rabbit rat iv po |
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