头孢吡肟致精神障碍

1例69岁女性尿毒症长期血液透析患者，因肺部感染给予头孢吡肟1．0g，2次／d静脉滴注。治疗3d后出现失语，神志淡漠，失眠，行为失常，脑电图检查示：轻至中度异常，未见尖、棘波。排除非惊厥性癫痫持续状态。疑为头孢吡肟所致精神障碍。第5天停用头孢吡肟，2d后患者完全恢复正常。

Psychiatric disturbance attributed to cefepime

A 69-year-old woman with uremia undergoing long-term hemodialysis was treated with an IV infusion of cefepime 1.0 g twice daily for pulmonary infection. Three days later, the woman developed aphasia, apathy, isomnia, and abnormal behaviors. An EEG examination showed mild-to-moderate abnormality without spike and sharp wave activity. Nonconvulsive status epilepticus was excluded. Cefepime-indueed psychiatric disturtanee was suspected. On day 5, eefepime was stopped. Two days later, she fully recovered.