| 5-单硝酸异山梨醇酯的合成 |
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| 引用本文： | 邢慧海,鲍杰,段梅莉. 5-单硝酸异山梨醇酯的合成[J]. 中国医药工业杂志, 2011, 42(7) |
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| 作者姓名： | 邢慧海 鲍杰 段梅莉 |
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| 作者单位： | 1. 华东理工大学药学院
2. 华东理工大学生物反应器工程国家重点实验室,上海,200237 |
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| 摘 要： | 山梨醇经脱水得到异山梨醇,用硅胶-活性炭过滤后,再经硝化、氢氧化钠成盐反应及中和反应等制得5-单硝酸异山梨醇酯,总收率约16%,纯度不低于99%。
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| 关 键 词： | 5-单硝酸异山梨醇酯 心血管药物 合成 |
Synthesis of Isosorbide 5-Mononitrate |
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| XING Huihai,BAO Jie,DUAN Meili. Synthesis of Isosorbide 5-Mononitrate[J]. , 2011, 42(7) |
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| Authors: | XING Huihai BAO Jie DUAN Meili |
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| Affiliation: | XING Huihai~1,BAO Jie~2,DUAN Meili~(1*) (1.School of Pharmacy,2.State Key Lab.of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237) |
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| Abstract: | Isosorbide 5-mononitrate was synthesized from sorbitol by dehydration to give isosorbide,which was purified by silicon-activated carbon filtration,and then underwent nitration,treatment with sodium hydroxide and neutralization with an overall yield of about 16%and purity of above 99%. |
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| Keywords: | isosorbide 5-mononitrate cardiovascular drug synthesis |
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