| 不同提取条件对丹酚酸B和E相对含量的影响 |
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| 引用本文： | 刘文静,阚士东,陈代杰,李继安,邵雷. 不同提取条件对丹酚酸B和E相对含量的影响[J]. 中国医药工业杂志, 2011, 42(7) |
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| 作者姓名： | 刘文静 阚士东 陈代杰 李继安 邵雷 |
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| 作者单位： | 中国医药工业研究总院上海医药工业研究院,创新药物和制药工艺国家重点实验室,上海200040 |
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| 基金项目： | 国家“重大新药创制”科技重大专项(2009ZX09301-007) |
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| 摘 要： | 通过HPLC、LC-MS等手段确定了丹参提取物中的小组分丹酚酸E,并考察了加水量、提取温度、时间和pH对丹酚酸B、E相对含量及丹酚酸B提取率的影响。结果显示:不同提取条件下,丹酚酸B、E相对含量变化显著,推测两者存在一定转化机制。丹酚酸B的最佳提取工艺为:丹参药材中加入8倍体积水,用1 mol/L盐酸调至pH 4 0,70℃提取60min,丹酚酸B的收率大于90%。
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| 关 键 词： | 丹参 丹酚酸B 丹酚酸E 提取 |
Relative Content of Salvianolic Acid B and Salvianolic Acid E under Different Extraction Conditions |
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| LIU Wenjing,KAN Shidong,CHEN Daijie,LI Ji'an,SHAO Lei. Relative Content of Salvianolic Acid B and Salvianolic Acid E under Different Extraction Conditions[J]. , 2011, 42(7) |
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| Authors: | LIU Wenjing KAN Shidong CHEN Daijie LI Ji'an SHAO Lei |
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| Affiliation: | LIU Wenjing,KAN Shidong,CHEN Daijie,LI Ji'an~*,SHAO Lei (State Key Lab.of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200040) |
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| Abstract: | The minor compound in the extract of Salvia miltiorrhiza Bunge was identified as salvianohc acid E by HPLC and LC-MS.Meanwhile,the influence of different extraction conditions,including the amount of water, temperature,extraction time and pH on the relative amount of salvianohc acid B and salvianohc acid E,as well as the relative yields of salvianohc acid B were investigated.The results showed that the relative amount of salvianohc acid B and salvianohc acid E changed a lot under different conditions,which ... |
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| Keywords: | Salvia miltiorrhiza Bunge salvianolic acid B salvianolic acid E extraction |
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