转移抑制基因nm23在肺癌中的表达与预后关系的研究

目的 探讨人非小细胞肺癌中nm23的表达水平与肺癌的转移及预后关系。方法 应用免疫组织化学法对146例人非细胞肺癌中nm23的表达水平进行研究。结果 肺癌中nm23表达水平明显低于癌旁肺组织和正常肺组织（P＜0.05），肺癌中nm23表达水平与肺癌细胞分化程度，是否存在转移有密切关系（P＜0.05），癌旁组织与正常肺组织之间无显著性差异（P＞0.05）。结论 nm23在非小细胞肺癌中起转移抑制基因的作用，它们的表达水平降低可能是肺癌转移的重要原因。

A study on the relationship between expression of nm23 gene and prognosis in patients with non-small cell luns cancer

Objective In order to explore the expression level of nm23 gene and its relationship with metastasis and prognosis in human non smal cell lung cancer(NSCLC).Methods The expression level of nm23 gene product was determind with immunohistochemistry in 146 NSCLC samples.Results The positive rate of nm23 expression in NSCLC was significantly lower than that in adjacent non tumor lung tissue and that in normal lung tissue (P<0.05).There were significant differences between nm23 expression and the rate of differentiation of the tumor and the tumor metastasis (P<0.05),but not to the adjacent non tumor lung tissue and that in normal lung tissue (P>0.05).Conclusions The results suggest that nm23 gene may be involved in the oncogenesis,development,and metastasis of human NSCLC and its expression decrease may be a key cause of lung cancer metastasis.