Cutaneous sclerosing Pacinian-like perineurioma |
| |
Authors: | O Burgues,C Monteagudo,R Noguera,A Revert,I Molina,& A Llombart-Bosch |
| |
Affiliation: | Department of Pathology, Hospital Clínico Universitario, University of Valencia, Valencia, Spain. |
| |
Abstract: | AIMS: The term perineurioma has been used to designate a variety of clinically and histologically different proliferations of perineurial cells based on immunohistochemical and/or ultrastructural characterization. There are two different groups of neoplasms derived from perineurial cells: extraneural or soft tissue perineuriomas, and intraneural perineuriomas. Recently, a sclerosing variant of cutaneous perineurioma has been described. METHODS AND RESULTS: We report a case of a cutaneous form of perineurioma, combining features of the intraneural and sclerosing varieties, as well as showing a Pacinian pattern of growth. In order to assess the neoplastic nature of the lesion, we performed fluorescence in-situ hybridization (FISH) analysis using a probe which maps to the chromosome band 22q11 and 22q13, allowing us to show deletion or loss of one chromosome 22 in the tumour cells. CONCLUSIONS: This case may be considered a new variant of perineurioma with Pacinian-like features, for which we propose the designation 'sclerosing Pacinian-like perineurioma'. |
| |
Keywords: | perineurioma perineurial cell nerve sheath tumour soft tissue FISH |
|
|