自体血回输中肝素含量对患者凝血功能的影响

目的观察回收的自体血中残留的肝素对患者凝血功能的影响。方法骨科择期手术患者40例,随机分为自体血回输组和异体血输血组,各20例患者,术前肝、肾、凝血功能均正常,无其他血液系统疾病。两组患者的输血量均超过800mL。采用ACT-Ⅱ型测定仪测定血中活化凝血时间ACT。结果ACT:自体血回输组二个不同时间分别为(88.42±16.36)s和(94.15±20.45)s;异体输血组分别为(86.50±18.24)s和(93.80±19.20)s。两组患者ACT术前与输血后1h差异无统计学意义(P>0.05)。结论自体血回输过程中使用适量肝素抗凝,对患者的凝血功能影响不大。

Effect of heparin concentration in transfused autoblood on coagulation function in surgical patients

Objective To observe the effect of reliqus heparin in transfused autoblood on coagulation function in surgical patients.Methods Forty patients for orthopaedics operations were randomly divided into autologous transfusion group (n=20) and allogenous blood transfusion group (n=20). All patients' preoperative measurements (liver function, renal function parameters and coagulation function) were normal, without hematological abnormity. Transfusion volume in all subjects exceeded 800 mL. Activated coagulation time (ACT) was measured with ACT-Ⅱ detector. Results Pre-and post-transfusion ACT was respectively (88.42±16.36)s and (94.15±20.45)s in autologous transfusion group; (86.50±18.24)s and(93.80±19.20)s in allogenous blood transfusion group. There was no significant difference in ACT measurement before operation compared with that one day after transfusion (P>0.05).Conclusion Proper dose of heparin doesn't exert a significant impact on blood coagulation function during autotransfusion.