| Effects of Hypoxia on Calmodulin Levels of Lung Tissues and Small Pulmonary Arterial Walls in Young Pigs |
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| 引用本文： | 喻明芙,孙秉庸,王仕军,王肇文. Effects of Hypoxia on Calmodulin Levels of Lung Tissues and Small Pulmonary Arterial Walls in Young Pigs[J]. 中国人民解放军军医大学学报, 1989, 0(3) |
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| 作者姓名： | 喻明芙 孙秉庸 王仕军 王肇文 |
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| 作者单位： | Department of Pathophysiology and Institute of High Altitude Medicine Third Military Medical Collge Chongqing，Department of Pathophysiology and Institute of High Altitude Medicine Third Military Medical Collge Chongqing，Department of Pathophysiology and Institute of High Altitude Medicine Third Military Medical Collge Chongqing，Department of Pathophysiology and Institute of High Altitude Medicine Third Military Medical Collge Chongqing |
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| 摘 要： | The effects of chronic hypoxia on calmodulin levels of lung tissues and small pulmonary ar-terial walls were studied in young pigs, The tissue specimens of hypoxic animals were obtained underhypoxic conditions. The following results were collected:(1) The swine exposed to chronic intermittent hypoxia showed a significant pulmonary pressor re-sponse at a simulated high altitude of 4000 m.(2) A higher level of calmodulin was found in the lung tissues of chronic hypoxic animals. It maybe related to the increased release of some vaosactive substances from pulmonary non-muscularcalls.(3) No significant difference of calmodulin level of small arterial walls was demonstrated between theexperimental animals and the control.The findings suggest that pulmonary vasoconstriction due to hypoxia is not likely to be associatedwith obvious change in calmodulin level in the smooth muscle of blood vessels.
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Effects of Hypoxia on Calmodulin Levels of Lung Tissues and Small Pulmonary Arterial Walls in Young Pigs |
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| Yu Mingfu,Sun Bingyong,Wang Shijun,Wang Zhaowen. Effects of Hypoxia on Calmodulin Levels of Lung Tissues and Small Pulmonary Arterial Walls in Young Pigs[J]. Journal of Medical Colleges of PLA(China), 1989, 0(3) |
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| Authors: | Yu Mingfu Sun Bingyong Wang Shijun Wang Zhaowen |
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| Affiliation: | Yu Mingfu,Sun Bingyong,Wang Shijun,Wang Zhaowen,Department of Pathophysiology,and Institute of High Altitude Medicine,Third Military Medical College,Changqing |
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| Abstract: | The effects of chronic hypoxia on calmodulin levels of lung tissues and small pulmonary ar- terial walls were studied in young pigs, The tissue specimens of hypoxic animals were obtained under hypoxic conditions. The following results were collected: (1) The swine exposed to chronic intermittent hypoxia showed a significant pulmonary pressor re- sponse at a simulated high altitude of 4000 m. (2) A higher level of calmodulin was found in the lung tissues of chronic hypoxic animals. It may be related to the increased release of some vaosactive substances from pulmonary non-muscular calls. (3) No significant difference of calmodulin level of small arterial walls was demonstrated between the experimental animals and the control. The findings suggest that pulmonary vasoconstriction due to hypoxia is not likely to be associated with obvious change in calmodulin level in the smooth muscle of blood vessels. |
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| Keywords: | hypoxia pulmonary hypertension calmodulin |
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