自发荧光支气管镜在肺癌诊断中应用的研究

目的:探讨自发荧光支气管镜检查在诊断肺癌中的应用价值。方法:选取103例行荧光支气管镜检查并最终经病理证实为肺癌的患者,比较行荧光支气管镜检查过程中白光状态和荧光状态的敏感度和特异度的差异,并计算荧光支气管镜检查肺癌的检出率。同时回顾分析100例行普通支气管镜检查并最终经病理证实为肺癌的患者,计算肺癌的检出率,并与荧光支气管镜检查的检出率相比较。结果:103例荧光支气管镜检查患者,白光和荧光状态的敏感度分别为83.3%、92.4%,特异度分别为75.7%、45.9%,差异有统计学意义(P<0.05)。荧光支气管镜和普通支气管镜肺癌的检出率分别为64.1%、53%,差异有统计学意义(P<0.05)。所有患者手术过程顺利,无死亡病例和严重并发症发生。结论:自发荧光支气管镜检查安全性高,肺癌诊断的敏感度高,使肺癌的检出率得到提高,在肺癌的诊断中有一定的应用价值。

Value of autofluorescence bronchoscopy in diagnosis of lung cancer

Objective To evaluate the role of autofluorescence bronchoscopy in diagnosis of lung cancer.Method 103 patients who were finally diagnosed lung cancer were examined with both white light bronchoscopy （WLB） and autofluorescence bronchoscopy （AFB） .Biopsy specimens were taken from all abnormal areas discovered by WLB and AFB examination for pathological examinations.Another group of 100 patients who were finally diagnosed lung cancer were examined only with WLB.Results 103 lung cancer patients were examined with WLB and AFB,the sensitivity were 83.3% and 92.4%,the specificity were 75.7% and 45.9%,respectively.There were significant difference between WLB and AFB examination （P〈0.05） .The detection rate of this group patients was 64.1%,and the detection rate of the other group patients who were examined only with WLB was 53%,there were significant difference between two groups （P〈0.05） .No complications were observed for the patients examined with AFB and WLB.Conclusion The result indicates that AFB examination in diagnosis of lung cancer has the higher safety and sensitivity,it can improve the diagnosis rate and has certain advantages in the diagnosis of lung cancer.