B型脑钠肽在慢性阻塞性肺疾病中的水平改变意义分析

目的：探讨B型脑钠肽在慢性阻塞性肺疾病中的水平变化关系并进行分析。方法选取本院2013年1~12月收治的58例慢性阻塞性肺疾病患者的临床资料，分为肺动脉高压组30例与肺动脉压正常组28例，另取同期来院体检正常者30例作为对照组，监测三组患者血浆B型脑钠肽（BNP）值与动脉血气分析值，通过心脏超声测定肺动脉压力，收缩末期右心室内径的大小、其与左室内径比。结果肺动脉高压组其血浆BNP水平、右室收缩末期内径、右室/左室内径比均明显高于肺动脉压正常组（P〈0.05）；肺动脉高压组其肺动脉压力与血浆BNP值呈正相关（r=0.42），肺动脉压正常组其血氧分压与血浆BNP呈负相关（r=-0.31）。结论慢性阻塞性肺疾病中血浆BNP是右室功能不全、肺动脉高压的敏感性指标。

Analysis on change of B-type brain natriuretic peptide levels in chronic obstructive pulmonary disease

Objective To explore the change of B-type brain natriuretic peptide levels in chronic obstructive pulmonary disease. Methods Choosing the clinical data of 58 patients with chronic obstructive pulmonary disease from January 2013 to December 2013 and dividing them into pulmonary hypertension group（38 cases） and pulmonary artery pressure normal group（20 cases）, another in the same period to normal hospital check-up 30 cases as control group, the monitoring of the three groups of patients with plasma B-type brain natriuretic peptide（BNP） value and arterial blood gas analysis, pulmonary artery pressure by cardiac ultrasound measurement, end systolic right ventricular diameter size, with the left interior diameter ratio. Results The plasma BNP levels, right ventricular end systolic diameter, right ventricular/left interior diameter of pulmonary hypertension group were significantly higher than pulmonary artery pressure normal group（P〈0.05）;the pulmonary artery pressure and plasma BNP value in pulmonary hypertension group was a positive correlation（r=0.42）, partial pressure of blood oxygen and plasma BNP in pulmonary artery pressure normal group was a negative correlation（r=0.31）. Conclusion Plasma BNP in chronic obstructive pulmonary disease is sensitive indexes of right ventricular dysfunction and pulmonary arterial hypertension.