针刺对肥胖大鼠杏仁核作用的研究

本实验采用高脂饲料喂养SD雄性大鼠制造肥胖动物模型 ,并观察针刺对其摄食、体重、脂肪、杏仁核组织单胺类神经介质含量的影响。结果显示 ,针刺可以明显降低肥胖大鼠摄食量、体重、Lee’s指数、脂肪量 ,说明针刺具有减肥作用。本文可见 ,肥胖大鼠杏仁核酪氨酸 (Tyr)、多巴胺 (DA)和去甲肾上腺素 (NA)的水平明显低于正常 ,而 5 羟色胺 (5 HT)和 5 HT/ 5 羟吲哚乙酸 (5 HIAA)的水平明显高于正常。针刺治疗取得良好减肥效应 ,同时肥胖大鼠杏仁核Tyr、DA水平明显回升 ,5 HT和 5 HT/ 5 HIAA水平明显回降。提示 ,针刺对肥胖大鼠杏仁核的良性作用可能是其实现减肥效应的中枢作用机制之一

Effect of Acupuncture on the Amygdala of Obese Rats

In this experiment the amount of food and water taken in,body weight,body fat,and monoamine content of amygdala in obesity model of male SD rats obtained by high fat diet were observed before and after acupuncture. The results showed that the contents of tyrosine (Tyr),dopamin(DA)and noradrenaline(NA)were lower in control group than those of normal,but the contents of serotonin(5 HT)and 5 HT/5 hydroxyindoleacetic acid(5 HIAA) were higher than those of normal.After acupuncture treatment,the weight loss was achieved while the level of Tyr and DA increased, the level of 5 HT and 5 HT/5 HIAA decreased in amygdala of obese rats. It suggests that a good regulative effect of acupuncture on amygdala of obese rat is an important link in the antibesity.