| Abstract: | The aqueous leaf extract of Cissampelous mucronata (Menispermaceae) was studied for spasmolytic properties. The extract inhibited the responses of histamine, acetylcholine and nicotine on the guinea-pig ileum in a dose-related manner. The extract completely abolished the spontaneous pendular movement of the rabbit jejunum reversibly, and decreased gastrointestinal motility in mice. It did not modify the effect of Ca2+ on the guinea-pig ileum. Acute toxicity tests in mice established the i.p. LD50 value of the extract to be 1698.24±77 mg/kg. |
