| 心钠素对内皮素生物学效应的拮抗作用 |
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| 引用本文： | 李辉,李俭春,江时森,唐朝枢.心钠素对内皮素生物学效应的拮抗作用[J].医学研究生学报,1993(2). |
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| 作者姓名： | 李辉 李俭春 江时森 唐朝枢 |
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| 作者单位： | 金陵医院心脏科，金陵医院心脏科，金陵医院心脏科，北京医科大学心肺研究室 |
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| 摘 要： | 为了探讨ANF对ET生物学效应的拮抗作用,我们进行了下述实验。在ET致小鼠死亡实验中,观察到大剂量ANF可显著延长小鼠存活时间;在ET致大鼠血压升高实验中,观察到ANF有明显拮抗ET的升压作用;在大鼠离体胸主动脉环灌流实验中,观察到ANF对ET引起的血管收缩呈浓度依赖性的舒张作用;在培养的血管平滑肌细胞(VSMC)中,观察到ANF有显著抑制ET的促VSMC钙内流作用。实验结果表明,ANF对ET生物学效应具有部分拮抗作用,ANF作为治疗与ET有关疾病的辅助药物,可能具有潜在的临床意义。
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| 关 键 词： | 心钠素 内皮素 血管平滑肌 血压 钙 |
The antagonized effects of atrial natriuretic factor on endothelin biological actions |
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| Li Hui.The antagonized effects of atrial natriuretic factor on endothelin biological actions[J].Bulletin of Medical Postgraduate,1993(2). |
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| Authors: | Li Hui |
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| Institution: | Department of Cardiology |
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| Abstract: | In order to investigate inhibitory effect of atrial natriuretic factor(ANF)on biological action of endothelin(ET),the in vivo and in vitro experiments were done.It was found that in the experiment of ET-induced death in mice,simultaneous treatment with large dose of ANF significantly prolonged animal survival time;and the administration of ANF to rat obviously inhibited its blood pressure elevation produced by ET.And ANF dose-dependently relaxed isolated perfused rat aortic ring,which was precontracted by ET.In cultured vascular smooth muscle cells,ANF markedly lowered ET- stimulated Ca~(2+) influx.The results showed that ANF partly antagonized ET biological actions, suggesting that ANF,as an adjuvant to treat diseases related to ET,might be of prespective significance on clinical application. |
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| Keywords: | atrial natriuretic factor(ANF) endothelin vascular smooth muscle blood pressure calcium |
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