| 正交试验法优选小儿平喘祛痰颗粒提取工艺 |
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| 引用本文： | 杨德斌,仝燕,马振山,王琳,董美虹,李艳玲,王锦玉. 正交试验法优选小儿平喘祛痰颗粒提取工艺[J]. 中国实验方剂学杂志, 2012, 18(21): 49-51 |
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| 作者姓名： | 杨德斌 仝燕 马振山 王琳 董美虹 李艳玲 王锦玉 |
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| 作者单位： | 1. 中国中医科学院中药研究所,北京100700;天津中医药大学,天津300193
2. 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 中国中医科学院基本科研业务费自主选题项目(2011XYCZ-07) |
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| 摘 要： | 目的:优选小儿平喘祛痰颗粒的提取工艺条件。方法:以盐酸麻黄碱、盐酸伪麻黄碱、橙皮苷提取量及干膏得率为评价指标,采用HPLC进行定量分析,通过L9(34)正交试验优选小儿平喘祛痰颗粒水提取工艺。结果:最佳水提取工艺条件为加10,8,8倍量水提取3次,提取时间依次为1.5,1,1 h。结论:该优选工艺稳定可行,可用于小儿平喘祛痰颗粒的工业化生产。
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| 关 键 词： | 小儿平喘祛痰颗粒 盐酸麻黄碱 盐酸伪麻黄碱 橙皮苷 水提取 正交试验 高效液相色谱法 |
| 收稿时间： | 2012-07-11 |
Optimization of Extraction Process of Xiaoer Pingchuan Qutan Granule by Orthogonal Design |
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| YANG De-bin,TONG Yan,MA Zhen-shan,WANG Lin,DONG Mei-hong,LI Yan-ling and WANG Jin-yu. Optimization of Extraction Process of Xiaoer Pingchuan Qutan Granule by Orthogonal Design[J]. China Journal of Experimental Traditional Medical Formulae, 2012, 18(21): 49-51 |
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| Authors: | YANG De-bin TONG Yan MA Zhen-shan WANG Lin DONG Mei-hong LI Yan-ling WANG Jin-yu |
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| Affiliation: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | Objective: To optimize extraction process conditions of Xiaoer Pingchuan Qutan granule. Method: Using extraction amount of ephedrine hydrochloride,pseudoephedrine hydrochloride,hesperidin and yield of dry extract as indexes,HPLC was used to quantitative analysis,water extraction technology of Xiaoer Pingchuan Qutan granule was optimized by L9(34) orthogoral design. Result: Optimum water extraction technology was as follows: extracted 3 times with 10,8,8 times the amount of water,extracted 1.5,1,1 h in turn. Conclusion: This optimized extraction technology was stable and feasible,it could be used in industrial production of Xiaoer Pingchuan Qutan granule. |
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| Keywords: | Xiaoer Pingchuan Qutan granule ephedrine hydrochloride pseudoephedrine hydrochloride hesperidin water extraction orthogonal design HPLC |
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