| 黄芪多糖联合顺铂治疗H22肝癌的实验研究 |
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| 引用本文： | 黄宏思,黄卫彤,韦鹏涯,黄衍强.黄芪多糖联合顺铂治疗H22肝癌的实验研究[J].时珍国医国药,2008,19(11). |
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| 作者姓名： | 黄宏思 黄卫彤 韦鹏涯 黄衍强 |
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| 作者单位： | 右江民族医学院,广西,百色,533000 |
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| 摘 要： | 目的观察黄芪多糖联合顺铂对小鼠H22肝癌移植瘤生长的抑制作用。方法复制H22肝癌小鼠移植瘤模型。将40只接种H22肝癌细胞昆明小鼠随机分成4组:对照组、黄芪多糖组(APS)、顺铂组(DDP)、联合组(APS DDP)。治疗期间,观察小鼠的毒副反应以及生存质量。实验19 d后,处死全部小鼠,剥离皮下肿瘤,称小鼠肿瘤重量,计算出抑瘤率。结果APS单用组的H22肝癌平均瘤重为(1.29±0.29)g,明显低于对照组的(1.86±0.73)g(t=3.975,P<0.001)。APS与DDP合用组的H22肝癌平均瘤重为(0.52±0.31)g,均明显低于APS单用组(t=9.935,P<0.001)和DDP单用组(t=4.197,P<0.001);其抑瘤率达72.0%,明显高于APS单用组(2χ=17.376,P<0.001)和DDP单用组(2χ=5.079,P<0.05)。联合治疗组小鼠毒副反应明显低于DDP组,生存质量优于DDP组。结论黄芪多糖和顺铂对小鼠H22肝癌移植瘤的生长具有协同抑制作用,并能降低顺铂毒副反应,提高生存质量。
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| 关 键 词： | 黄芪多糖 顺铂注射液 H22肝癌移植瘤 |
Experimental Research on Astragalus Polysaccharides Combined with Cisplatin in Treating H22 Liver Cancer |
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| HUANG Hong-si,HUANG Wei-tong,WEI Peng-ya,HUANG Yan-qiang.Experimental Research on Astragalus Polysaccharides Combined with Cisplatin in Treating H22 Liver Cancer[J].Lishizhen Medicine and Materia Medica Research,2008,19(11). |
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| Authors: | HUANG Hong-si HUANG Wei-tong WEI Peng-ya HUANG Yan-qiang |
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| Institution: | Youjiang Medical College for Nationalities;Baise 533000;China |
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| Abstract: | Objective To research the inhibitory action of Astragalus polysaccharides(APS) combined with cisplatin(DDP) in treating H22 liver cancer in mice.Methods H22 liver cancer cells were inoculated into the mammary fatty pad of mice to establish H22 liver cancer model,40 mice bearing highly metastatic H22 liver cancer cells were randomized into four groups: control group,DDP group,APS group,APS DDP group.Different treatments were served from day 7 after transplantation and all mice were sacrificed after 19 days.... |
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| Keywords: | Astragalus Polysaccharides Cisplatin injection Murine hepatoma H22 liver cancer |
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