低剂量5-氟脲嘧啶持续输注联合低剂量顺铂治疗晚期消化道恶性肿瘤

目的：观察低剂量5-氟脲嘧啶（5—FU）持续输注联合低剂量顺铂（PDD）方案治疗晚期消化道恶性肿瘤的疗效。方法：5－FU250mg．m－2．d－1，持续深静脉输注3～4周。PDD6mg．m-2．d-1，静脉输注1小时，每周用5天，连用3～4周。以上方案连用二周期为一疗程，化疗后休息1个月评定疗效。结果：全组24例，总有效率为54．17％，其中PR13例。胃癌、食管癌、结肠癌的有效率分别为：64.29％、50．00％、33．33％；肝转移灶的有效率较高为75．00％。中位缓解期4．5个月（2～8个月）。没有Ⅲ°～Ⅳ°毒副反应发生。结论：认为低剂量5－FU持续输注联合低剂量PDD方案治疗晚期消化道恶肿瘤是一个有效低毒的化疗方案。

Combined Chemotherapy of Continuous Infusion of Low-dose of 5-Fluorouracil and Low-dose of Cisplatin in Advanced or Recurrent Gastrointestinal Carcinoma

ObjectivesTo evaluate the efficacy and toxicity of the continuous central venous infusion (c.c.v.i) of low-dose of 5-fluorouracil with low-dose of cisplatin (PDD). Methods Twenty-four patients with advanced or recurrent gastrointestinal carcinoma(14 in stomach,4 in esophagus,and 6 in colon)were observed in this study.5-Fu was given with a dosage of 250mg^.m^-2.d^-1.c.c.v.i.for 3-4 weeks,and PDD with a dosage of 6mg .m^-2.d^-1.infused in one hour,five times a week, and lasted for 3-4weeks. Two treating courses were carried out with a pne month interval in between. Results The overall response rate was 54.17%(13/24), including 13 cases of partial responses. The response rates of gastric, esophageal, and colonic cancers were 64.29%(9/14),50.00%(2/4) and 33.33%(2/6)respectively. An especially high response rate of 75% was seen in 12 cases with liver metastasis. The mean duration of response was 4.5 months (range 2-8 months). No severe side effects occurred in any of the cases. Conclusions It is indicated that a combined chemotherapy of daily low-dose of 5-Fu with PDD is an effective method in the treatment of advanced or recurrent gastrointestinal carcinoma.