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Serum zinc and serum lipid profiles in 778 adults |
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| Authors: | Rita Hiller MS Daniel Seigel ScD Robert D. Sperduto MD Norman Blair MD Thomas C. Burton MD Marilyn D. Farber PhD Evangelos S. Gragoudas MD Elaine W. Gunter BS Julia Haller MD Johanna M. Seddon MD Anne L. Sowell PhD Lawrence A. Yannuzzi MD The Eye Disease Case-Control Study Group |
| Affiliation: | a From the Division of Biometry and Epidemiology, National Eye Institute, Bethesda, MD, U.S.A. b From the University of Illinois, Chicago, IL, U.S.A. c From the Medical College of Wisconsin, Milwaukee, WI, U.S.A. d From the Massachusetts Eye and Ear Infirmary, Boston, MA, U.S.A. e From the Centers for Disease Control and Prevention, Atlanta, GA, U.S.A. f From the Wilmer Eye Institute, Baltimore, MD, U.S.A. g From the Manhattan Eye, Ear, and Throat Hospital, New York, NY, U.S.A. |
| Abstract: | There has been increasing use of high-dosage zinc supplementation in the population, in particular as a potential treatment for age-related macular degeneration. We examined the relationship between fasting serum zinc and serum lipid levels in 778 adults, aged 22 to 80 years, who were control subjects in a multicenter, clinic-based case-control study. The samples were taken during 1987 to 1990, a time when vitamin/mineral supplementation was becoming increasingly common. We found that higher serum zinc levels, most notably those above the highest quintile, were associated with higher levels of total serum cholesterol, low-density-lipoprotein cholesterol, and triglycerides. No significant trend was noted for high-density-lipoprotein cholesterol. Previous studies demonstrated that high-dosage zinc supplements raise serum zinc levels. The possibility that use of such supplements can adversely affect serum lipid profiles suggests that chronic ingestion of such supplements should not be done without adequate medical supervision. |
| Keywords: | Author Keywords: Serum zinc total serum cholesterol low-density-lipoprotein cholesterol high-density-lipoprotein cholesterol triglycerides |
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