| 重组人p53腺病毒对肝癌细胞作用的病理学观察 |
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| 引用本文： | 杨倩,关弘,张家庭,李征毅. 重组人p53腺病毒对肝癌细胞作用的病理学观察[J]. 云南医药, 2010, 0(2): 136-139 |
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| 作者姓名： | 杨倩 关弘 张家庭 李征毅 |
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| 作者单位： | [1]昆明市第一人民医院病理科,云南昆明650011 [2]深圳市第二人民医院病理科,广东深圳418035 [3]深圳市第二人民医院B超科,广东深圳418035 |
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| 摘 要： | 目的观察重组人p53腺病毒注射液（rAd—p53）瘤内注射对肝癌细胞的作用。方法20例兔肝细胞癌动物模型，分为2组，每组10例，A组瘤内注射rAd—p53，B组瘤内注射生理盐水。治疗后取肿瘤组织进行病理学观察及凋亡检测（TUNEL法）。结果A组凋亡指数（AI）为6．44±1．91，B组为2．46±1．21，2组之间统计学有显著性差异。结论rAd—p53对肝细胞癌有明显的抑制作用。
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| 关 键 词： | 肝细胞癌 基因治疗 重组人P53腺病毒 凋亡 |
The pathologic investigation on the effects of the recombinant adenoviral vector tAd-p53 on hepatic cell careinoma |
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| Affiliation: | YANG Qian,GUAN Hong, ZHANG Jia-ting, et al. (Pathologic Department, The First People＇s Hospital of Kunming, Kunming 650011, China) |
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| Abstract: | Objective To investigate the effects of the recombinant adenoviral vector rAd-p53 on hepatic cell carcinoma. Methods 20 rabbits bearing hepatic cell carcinomas were divided into 2 groups, group A were injected with rAd-p53; group B injected saline. Microscopic observation and apoptosis test were used. Results Apoptosis index of group A was 6.44 ± 1.91, group B was 2.46 ±1.21. Conclusion Hepatic carcinoma cells underwent significant apoptosis and necrosis after rAd-p53 injection. |
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| Keywords: | Hepatic cell carcinoma Gene-therapy Recombinant adenoviral vector （rAd-p53） Apoptosis |
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