Conventional dose of omeprazole alters gastric flora |
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Authors: | Y. Karmeli MD R. Stalnikowitz MD R. Eliakim MD Dr. G. Rahav MD |
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Affiliation: | (1) Department of Internal Medicine, Hadassah Mount Scopus, and Microbiology and Infectious Diseases, Hadassah Ein Kerem, Israel;(2) Department of Clinical Microbiology and Infectious Diseases, Hadassah Medical Center, 91120 Jerusalem, Israel |
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Abstract: | Quantitative cultures were carried out on samples from gastric juice obtained from 12 ambulatory patients with esophagitis before and one month after omeprazole therapy. An increase in the number of patients in whom gastric juice was culture-positive, as well as an increment in the bacterial counts were noted. The spectrum of microorganisms isolated from gastric juice was identical to the normal flora of the oral cavity, mainly -hemolytic streptococci, corynebacteria, andCandida species. Thus, the counts of organisms within gastric contents are simply a reflection of swallowed oral, microflora that were able to survive due to the less acidic environment. |
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Keywords: | omeprazole gastric pH gastric microorganism |
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